Histopathological alterations of male and female reproductive systems induced by alloxan in rats

Ismail, Hana Kh.

doi:10.33899/ijvs.2020.126626.1351

Cited by 8 publications

(9 citation statements)

References 24 publications

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“…Oxidative damage is initiated by imbalance between oxidant and antioxidant resulting in mitochondrial damage and DNA damage which are the main manifestation of oxidative stress that occurs in cadmium toxicity [14], [15]. Concomtant use of antioxidants produce improvement in the histological structure of the organ, this finding is in agreement with the finding of other workers [16], [17], [18], [19], [20].…”

Section: Discussionsupporting

confidence: 86%

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Al-Sammak

2021

Open Access Maced J Med Sci

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This study is to detect the toxic effect of cadmium chloride on the histological structure of the lung and the effect of parsley oil to amilorate these changes In this experiement 40 adult male mice were divided into four groups. Goup A (control group) in this group animals were injected with the normal saline intraperitoneally single daily dose for 30 days. Group B injected intrapertioneally with cadmium chloride single daily dose 3.5 mg/kg body weight for 30 days. Group C injected intraperetonially with cadmium chloride in a dose of 3.5 mg/kg body weight. Intragastric tube was put to recieve parsley oil in a dose of 0.5 ml/kg body weight prior to cadmium injection. The two drugs were given for 30 days. Group D recieved 0.5 ml/kg body weight by intragastric tube of parsley oil for 30 days. At the end of this experiement, the animals were sacrified the lungs were collected from all groups and prepared for light microscopical examination. Histological changes were detected in cadmium chloride treated group in comparison with the control group including congestion, inflammatory cell infiltration, interstial pneumonia (decreased alveolar space), thickening of interalveolar septum and damge to the alveolar cells. All these changes were eliminated by giving parsley oil.

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Section: Discussionsupporting

confidence: 86%

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Al-Sammak

2021

Open Access Maced J Med Sci

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“…Also, the phenolic property of silymarin acts to stabilize the free radicals and ROS by donation them electron and therefor preventing lipo-peroxidation by assistance the communication with cellular non-enzymatic antioxidants (24). A developed antioxidant system has been found in the reproductive organs (25), particularly gonads, where this antioxidants have a vital role in protecting reproductive tissues against free radicals and, in turn, preventing their negative effects on reproduction (20). On the other hand, different herbal extracts and herbal-derived substances have protective effects in the reproductive system.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, different herbal extracts and herbal-derived substances have protective effects in the reproductive system. From these herbal extracts, Silymarin was considered as a potent antioxidant agent that can protect most of the biological tissues, including reproductive tissues, such as germ cells (25).…”

Section: Discussionmentioning

confidence: 99%

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Abdulshaheed¹,

Al-Saaidi²,

Al-Arak³

2021

IJVS

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This study was conducted to qualify the ameliorating potency of silymarin against toxicity in ethidium bromide (EtBr) treated female rats. Eighty female Wistar rats aged 100 days, weighted 170-175 g were randomly allocated to control, orally supplemented with drinking water, and three treated groups, orally supplemented with silymarin 200 mg/kg BW, EtBr 10 mg/kg BW, and combination of EtBr and silymarin (SEtBr), respectively. Each group was allocated to two subgroups, sacrificed after 20 and 40 days of treatment. Bodyweight gain, uteri, and ovaries weight were recorded. Ovarian samples were obtained for histopathological examination. EtBr group females recorded the lowest body weight gain, relative weights of ovaries and uteri, and ovarian follicle number, whereas S group females recorded the highest body weight gain and follicular number, while the ovaries and uteri weights were either higher or close to the control group, at both experimental periods. Histopathological findings of both periods revealed necrosis, cirrhosis, ischemia, and prominent hemorrhage in the blood capillaries in EtBr treated ovarian tissues, but many of the ovarian follicles being mature and the atretic follicles were hence found to be high in number, whereas silymarin treated females showed normal ovarian tissues and viable ovarian follicles as that in control females. The combinationtreated females, at 20 days, revealed necrotic primary ovarian follicles with some macrophages infiltration, whereas 40 days' period showed normal ovarian cortex, medulla, and ovarian follicles. In conclusion, silymarin treatment in combination with EtBr has a potent amelioration effect against ovarian toxicity, in a duration-dependent manner.

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“…Also oxidative stress may occur owing to hyperglycemia (28). Hyperglycemia results from caffeine intake, the caffeine reduces the sensitivity of tissues toward insulin, impairs metabolism of glucose, and stimulates stress hormones release (as adrenaline) (26,29).…”

Section: Discussionmentioning

confidence: 99%

Histopathological changes in kidney and pancreas induced by energy drinks in adult male rats

Qassim¹,

Al-Sammak²,

Ayoob³

2021

IJVS

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The study aims to assess the impact of various doses of red bull on kidney and pancreas of male albino rats. Thirty male albino rats were assigned to three groups (10 animals/ group). Control group 1 received standard diet and water, group 2 and group 3 received daily oral doses of 10 ml/kg/rat and 20 ml/kg/rat of the energy drink (red bull) respectively for 30 days. Under light microscope no tissue changes were seen in kidney and pancreas of control group. In group 2 red bull causes vacuolar degeneration as well as coagulative necrosis of renal tubular epithelium, vascular congestion in the glomeruli and in the interstitial space of the kidney, in addition to atrophy of the glomeruli, as regard to pancreas it causes vascular congestion of the islets of Langerhans, increase in the size of the islets, besides, necrosis of Langerhans cells. In group 3 red bull leads to more atrophic glomeruli, massive coagulative necrosis of renal tubular epithelium, marked vascular dilatation and congestion in the interstitial space and degenerative changes of the renal tubular epithelium, whereas the pancreatic tissue revealed reduction in the size of the islets of Langerhans, vacuolation and degeneration of their cells, necrosis of other islets with mononuclear inflammatory cells infiltration and degenerative changes of pancreatic acini. It is concluded that administration of red bull to rats for 30 days will affect the histological structure of kidney as well as pancreas and this effect is a dose dependent.

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Histopathological alterations of male and female reproductive systems induced by alloxan in rats

Cited by 8 publications

References 24 publications

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Histopathological changes in kidney and pancreas induced by energy drinks in adult male rats

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