Histopathologic Validation of Fourier-Ellipsometry Measurements of Retinal Nerve Fiber Layer Thickness

Weinreb, Robert N.; Dreher, Andreas W.; Coleman, Anne L.; Quigley, Harry A.; Shaw, Blake R.; Reiter, Klaus

doi:10.1001/archopht.1990.01070060105058

Cited by 435 publications

(304 citation statements)

References 12 publications

(1 reference statement)

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“…General principles of SLP and its operation have been reported previously. 5 In brief, the device uses a diode laser with a wavelength of 780 nm to create the polarized laser beam, 6 which is directed to the retina, and the reflected light that doublepasses the RNFL is detected to obtain the retardation image at that point. The GDx VCC incorporates the method of VCC, which has been described elsewhere.…”

Section: Slpmentioning

confidence: 99%

Comparison of the GDx VCC scanning laser polarimeter and the stratus optical coherence tomograph in the detection of band atrophy of the optic nerve

Monteiro

Moura

2007

Eye

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Aim To compare the ability of scanning laser polarimeter (SLP) with variable corneal compensation (GDx VCC) and optical coherence tomograph (Stratus OCT) to discriminate between eyes with band atrophy (BA) of the optic nerve and healthy eyes. Methods The study included 37 eyes with BA and temporal visual field (VF) defects from chiasmal compression, and 29 normal eyes. Subjects underwent standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) scans using GDx VCC and Stratus OCT. The severity of the VF defects was evaluated by the temporal mean defect (TMD), calculated as the average of 22 values of the temporal total deviation plot on SAP. Receiver operating characteristic (ROC) curves were calculated. Pearson's correlation coefficients were used to evaluate the relationship between RNFL thickness parameters and the TMD. Results No significant difference was found between the ROC curves areas (AUCs) for the GDx VCC and Stratus OCT with regard to average RNFL thickness (0.98 and 0.99, respectively) and the superior (0.94; 0.95), inferior (0.96; 0.97), and nasal (0.92; 0.96) quadrants. However, the AUC in the temporal quadrant (0.77) was significantly smaller (Po0.001) with GDx VCC than with Stratus OCT (0.98). Lower TMD values were associated with smaller RNFL thickness in most parameters from both equipments.Conclusion Adding VCC resulted in improved performance in SLP when evaluating eyes with BA, and both technologies are sensitive in detecting average, superior, inferior, and nasal quadrant RNFL loss. However, GDx VCC still poorly discriminates RNFL loss in the temporal quadrant when compared with Stratus OCT.

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Section: Slpmentioning

confidence: 99%

Comparison of the GDx VCC scanning laser polarimeter and the stratus optical coherence tomograph in the detection of band atrophy of the optic nerve

Monteiro

Moura

2007

Eye

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“…4,5 Scanning laser polarimetry (SLP) has successfully been used to measure thickness of the nerve fibre layer outside the fovea. [6][7][8] Also, polarimetry images of the fovea show a characteristic 'bowtie' pattern. [9][10][11][12][13][14][15][16][17][18][19][20] This pattern is thought to result from an interaction of corneal and foveal birefringence.…”

Section: Introductionmentioning

confidence: 99%

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Weber

Elsner

Miura

et al. 2006

Eye

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Purpose To investigate the relationship between visual acuity and foveal birefringence in patients with neovascular age-related macular degeneration. Methods In total, 40 patients with choroidal neovascularization underwent macular imaging with scanning laser polarimetry. Bowtie patterns, typically seen in birefringence images of the macula, were evaluated and classified into three categories: (1) regular bowtie present; (2) bowtie present, but disrupted; and (3) no bowtie present. The relation of the bowtie appearance to the best-corrected logMAR visual acuities was tested (ANOVA). Results Mean visual acuity was best for the group that had regular bowties (mean logMAR ¼ 0.34) and differed statistically significantly from the disrupted bowtie group and no bowtie group (P ¼ 0.01 and 0.0007). Ages for the three groups did not differ (P ¼ 0.31). Conclusions Appearance of a regular bowtie indicates a substantially intact Henle fibre layer with the potential for good visual function, despite the presence of underlying pathology. Conversely, disruption or absence of a bowtie may indicate severe damage to the photoreceptors, consistent with the finding of poorer visual acuity.

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“…Polarized light crossing tissues with form birefringence properties undergoes retardation linearly related to thickness in a primate model. 1 The greater the retardation, the thicker the tissue. During the clinical course of glaucomatous optic neuropathy, standard automated perimetry (SAP) detects a glaucoma-related visual field (VF) defect only after at least a 40% loss of retinal ganglion cells has already occurred.…”

Section: Introductionmentioning

confidence: 99%

Atypical pattern of retardation on GDx-VCC and its effect on retinal nerve fibre layer evaluation in glaucomatous eyes

Pozzo

Marchesan

Canziani

et al. 2005

Eye

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Histopathologic Validation of Fourier-Ellipsometry Measurements of Retinal Nerve Fiber Layer Thickness

Cited by 435 publications

References 12 publications

Comparison of the GDx VCC scanning laser polarimeter and the stratus optical coherence tomograph in the detection of band atrophy of the optic nerve

Comparison of the GDx VCC scanning laser polarimeter and the stratus optical coherence tomograph in the detection of band atrophy of the optic nerve

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Atypical pattern of retardation on GDx-VCC and its effect on retinal nerve fibre layer evaluation in glaucomatous eyes

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