Histopathologic features of and lymphoid populations in the skin of patients with the spotted fever group of rickettsiae: southern Africa

Kim, Jessica; Smith, Kathleen J.; Naefie, Ronald; Skelton, Henry G.

doi:10.1111/j.1365-4632.2004.01560.x

Cited by 13 publications

(9 citation statements)

References 13 publications

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“…There were no epidermal changes seen in these four patients. 13 Medium-sized vessel involvement has not been reported with rickettsiae, though we saw it with four (11.4%) of our patients. Two of these patients had isolated medium vessel vasculitis, while the other two had a combination of medium and small vessel vasculitis.…”

Section: Discussioncontrasting

confidence: 41%

Clinicopathological study on rickettsial spotted fever from south India

et al. 2018

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Section: Discussioncontrasting

confidence: 41%

Clinicopathological study on rickettsial spotted fever from south India

et al. 2018

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“…Histological findings in ATF eruption are varied; one report showed more abundant neutrophil infiltration than that seen in Mediterranean spotted fever caused by R. conorii (9), but another showed only mononuclear cells, but not neutrophils, infiltrating into the dermis (10). In the present case, most infiltrated cells were immunohistochemically identified as helper T lymphocytes.…”

Section: Discussionmentioning

confidence: 79%

Rickettsia africae Infection in a Japanese Traveller with Many Tick Bites

Fujisawa¹,

Kadosaka²,

Fujita³

et al. 2012

Acta Derm Venerol

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“…5 Cell-mediated responses are performed by T-lymphocytes, whose main functions in combating intracellular pathogens are reduced to two categories: releasing cytokines, thus inducing an infl ammatory response, and causing lysis of cells that express specifi c antigens (cytotoxicity). 17,18 Investigations on CD8 + T-cell role in the antirickettsial immunity in animal models and study of the CD8 + T-cells in the perivascular infl ammatory infi ltrates in patients with rickettsial infection 19,20 have shown that endothelium plays an important role in the antigen presentation. 21 It has also been established that endothelial antigen presentation induced activation and proliferation of memory Т-cells, as well as antigen specifi c transmigration of T-lymphocytes in the perivascular infi ltrates.…”

Section: Discussionmentioning

confidence: 99%

“…27 Investigations on the perivascular infi ltrate cell composition provided evidence to this understanding. 19,20 Apoptosis could also play a role in the immune cell depression in the circulation. 15,27 CD38 co-stimulatory proteins are expressed selectively in higher amounts in the process of activation of mature T-cell subsets with increased capacity of IL-2 and IFN-γ cytokine production.…”

Section: Discussionmentioning

confidence: 99%

Clinical Investigations. T-Lymphocyte Subset Absolute Counts in the Peripheral Blood of Mediterranean Spotted Fever Patients: Relations to Disease Severity / Абсолютное Количество Субпопуляций Т-Лимфоцитов В Перифери- Ческой Крови Пациентов Со Средиземноморской Пятнистой Лихо- Радкой: Установление Связи С Тяжестью Заболевания

Baltadzhiev¹,

Pavlov²

2015

Folia Medica

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INTRODUCTION: Mediterranean spotted fever (MSF) in Bulgaria is caused by Rickettsia conorii conorii. Aim:This study aims at investigating the absolute counts of T-lymphocyte subsets in the peripheral blood of patients with MSF in order to establish relationships with disease severity. MATERIALS AND METHODS: The absolute counts of T-lymphocyte subsets were tested in the blood of 62 patients in the acute stage of MSF. They were assigned into three age and sex matched groups, based on the severity of disease -with mild, moderate or severe forms. Controls were 32 age and sex matched healthy individuals. The diagnosis was confi rmed by an immunofl uorescence assay. Immunophenotyping was performed using Epics XL-MCL Coulter, USA fl ow-cytometer. RESULTS: The absolute counts of immune competent (CD3 + ) cells, as well as the counts of helper/inducer (CD3 + CD4 + ) and suppressor/ cytotoxic (CD3 + CD8 + ) T-cell subsets decreased in parallel with disease severity. Naïve (CD4 + CD45RA + ) and activated memory (CD4 + CD45RO + ) T-cell subsets were reduced, particularly in severe MSF. Taken as a whole, the counts of activated (CD3 + HLA-DR + ) and that of presenting accessory (CD28 + ) or stimulatory (CD38 + ) molecules Т-cell subsets was increased, but in the fi rst two subsets the trend from mild to severe forms of the disease was descending. CONCLUSION: Reduced T-lymphocyte subset counts are likely related to trans-migration into perivascular infl ammatory foci. The increased number of T-lymphocytes bearing activation molecules refl ects a mobilization of the cell-mediated immune response. An important issue of this study is the possible prognostic value of T-cell subsets counting, predicting the evolution of a clinical condition to clinical forms, according to the disease severity. Т-лимфоцитов (CD4+CD45RA+), как и активированных Т-клеток памяти (CD4+CD45RO+) уменьшается количественно преимущественно при тяжёлых формах СПЛ. В общей сложности абсолютное количество активированных (CD3+HLA-DR+) и экспрессирующих акцессорные (CD28+) или стимуляторные (CD38+) молекулы Т-клеток повышено, но в первых двух субпопуляциях тренд от лёгких к тяжёлым формам заболевания является нисходящим. ЗАКЛЮЧЕНИЕ: Пониженные количества субпопуляций Т-лимфоцитов вероятно связаны с трансмиграцией в очаг воспаления. Повышенное количество Т-лимфоцитов, несущих активационные маркеры отражает мобилизацию клеточно-опосредованного иммунного ответа. Важным выводом исследования является возможное прогнозируемое количество Т-клеточных субпопуляций, предсказывающих трансформацию клинического состояния в клиническую форму в соответствии с тяжестью заболевания. Medica 2015; 57(2): 93-103 Ключевые слова: средиземноморская пятнистая лихорадка, субпопуляции Т-лимфоцитов -абсолютное количество, корреляции с тяжестью заболевания Folia

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Histopathologic features of and lymphoid populations in the skin of patients with the spotted fever group of rickettsiae: southern Africa

Cited by 13 publications

References 13 publications

Clinicopathological study on rickettsial spotted fever from south India

Clinicopathological study on rickettsial spotted fever from south India

Rickettsia africae Infection in a Japanese Traveller with Many Tick Bites

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