Histopathologic and clinical characterization of cardiac myxoma: Review of 53 cases from a single institution

Pucci, Angela; Gagliardotto, Piervincenzo; Zanini, Cristina; Pansini, Stefano; Summa, Michele di; Mollo, F

doi:10.1067/mhj.2000.107176

Cited by 153 publications

(113 citation statements)

References 15 publications

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“…There are mainly two views: (1) derived from pluripotent primitive mesenchymal cells (Pucci et al, 2000;Amano et al, 2003); (2) from the endocardial nerve tissue (Sakamoto et al, 2004). Some study put forward the idea that simplex virus type I (HSV-1) infection may be related with sporadic atrial myxoma In this study, tumor cells were CD34 positive, which support the idea of origin from the primitive mesenchymal cells with the ability to differentiate endothelium in the first view.…”

Section: Discussionsupporting

confidence: 66%

“…Most tumors stromal had different amount of lymphocytes, plasma cells and tissue cells, which may be related to the body's reaction. Author (Pucci et al, 2000) had summarized that in the 53 cases with cardiac myxoma, two cases had the spotty adenoid differentiation parts in the tumor basement. In this group, adenoid structure was identified in a 3-year-old child, which is rare in the cardiac myxoma and due to metaplasia from tumor cell, or differentiation from pluripotent stem cells.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Zheng

Xu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Zheng

Xu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…[8][9][10][11][12][13][14][15] The morphologic studies, such as those on vascular proliferation, hyaline formation, congestive areas, inflammation, hemorrhagic foci, calcification, and multiple giant cells, were not statistically significant for clinical presentations as in previous reports. [8][9][10][11][12] Moreover, the findings of apoptotic changes in cardiac myxoma were compatible with previous studies. 13,28 Apoptosis, commonly referred to as programmed cell death, involves the continuous destruction of nonfunctional cells.…”

Section: Discussionmentioning

confidence: 71%

“…7 Myxoma is the most common benign neoplasm of the heart. [8][9][10][11][12][13][14][15] Cardiac myxoma is associated with many mucopolysaccharidic matrices, including glycosaminoglycans 14,15 and proteoglycans. These glycoproteins may serve as receptors for the entry of HSV-1, 16,17 human papillomavirus (HPV), 18 and EBV.…”

mentioning

confidence: 99%

Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein–Barr virus

et al. 2005

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Cardiac myxoma is the most common tumor of the heart, has a variable clinical presentation and immunohistochemical profile. Viral infections, such as herpes simplex virus, human papillomavirus (HPV), and Epstein-Barr virus (EBV), may play an important role in the causes of cardiac myxoma. This investigation will demonstrate caspase-3-dependent apoptosis in cardiac myxoma without HPV or EBV infection. This study included 15 patients with cardiac myxoma, who were treated with surgical excision of the lesion. Data were collected on detailed clinical parameters. Terminal deoxynucleotidyl transferase nick-end labeling assay, electrophoresis, and caspase-3 immunohistochemical studies were performed to characterize apoptosis. Genechip containing 39 subtypes was used to elucidate HPV; and polymerase chain reaction to detect LMP-1 gene of EBV. The patient population comprised of eight (53%) women and seven (47%) men. The mean age of patient participants was 45 years, with an age range of 30-70 years. All patient cases were sporadic myxomas rather than familial myxomas. The patient presentations included dyspnea (53%), asymptomatic (27%), stroke (7%), chest pain (7%), and fever (7%). All lesions were located in the left atrium. The individual patient cases of myxoma did not differ in location or clinical event in terms of pathological scores, such as vascular proliferation, inflammation, cellularity, hyaline, calcification, or thrombosis. Cardiac myxoma is characterized by apoptosis through caspase-dependent pathway. HPV or EBV was not detected in any of the study patient samples. In conclusion, no viral genomes of HPV or EBV were detected in these 15 patients. This study demonstrates that caspase-3-dependent apoptosis in cardiac myxoma is not dependent on concurrence of previous HPV and/or EBV infection.

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“…Cardiac MRI generally is preferred imaging modality for these purpose. Primary cardiac neoplasias are rare and myxoma is the most common primary cardiac neoplasm [7] . In contrast to primary malignant cardiac tumors, metastatic involvement of the heart is relatively common and a sign of poor prognosis [8] .…”

Section: Discussionmentioning

confidence: 99%

Huge left atrial thrombus infected with aspergillusfumigatus

Kızıltunç

Taçoy

Aki

2014

IJDI

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Twenty three year old man with Hodgkin lymphoma had a resistant fever although treatment with broad spectrum antibiotics. Transthoracic echocardiography was performed to explain the origin of the fever and a huge mass was detected in the left atrium. Cardiac magnetic resonance imaging was performed and reported as intracardiac thrombus. Patient was referred to surgery. Culture of the surgical material favored to Aspergillus fumigates. Voriconazole treatment was started and patient recovered. The authors report overlapping two different clinical situations, intracardiac thrombus and fungal infective endocarditis.

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Histopathologic and clinical characterization of cardiac myxoma: Review of 53 cases from a single institution

Cited by 153 publications

References 15 publications

Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein–Barr virus

Huge left atrial thrombus infected with aspergillusfumigatus

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