Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Zheng, Jiayi; Xu, Geng; Wang, Hai-Chen; Yan, Yang; Wang, Hongyan

doi:10.7314/apjcp.2013.14.3.1743

Cited by 39 publications

(50 citation statements)

References 18 publications

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“…Compared with this record, our patients are slightly older, with an average age of 45.3 years. To the authors' knowledge, the youngest CMs patient was 3 years old [1], and the youngest patient in our study was 23 years old. In a previous study, Elbardissi et al [11] reported that male-to-female ratio of the CMs patients was 1:2.7, which suggests CMs are more prevalent in females.…”

Section: Discussionmentioning

confidence: 96%

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The Value of Multi-slice CT Imaging in Cardiac Myxomas in Comparison with Follow-Up Screening in Thoracoscopic Surgery

Hong-jun

Liang

Tan

2015

Cell Biochem Biophys

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In this study, we evaluated the ability of multi-slice CT (MSCT) imaging for the diagnosis of cardiac myxomas (CMs) in comparison with follow-up screening in thoracoscopic surgery. 40 consecutive patients who had CMs confirmed by thoracoscopic surgery underwent MSCT scanning. The radiological findings were analyzed to reveal the tumor location, appearance, size, pedicle diameter and originating, and compared with surgical outcomes in the follow-up studies. We found that the tumor location and appearance were all definitely diagnosed in the radiological findings and were consistent with the surgical outcomes with the coincidence rate of 100 %. All the tumors showed heterogeneous enhancement, with a pedicle originating from the atrial septum. Compared with the results of surgical outcomes, the accuracy of MSCT for measuring tumor size and pedicle diameter has no statistical difference. The results indicate that MSCT imaging provides a great incremental value for the diagnosis of CMs in comparison with follow-up screening in thoracoscopic surgery.

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Section: Discussionmentioning

confidence: 96%

“…CMs have an annual incidence rate of about 0.5 case per million people [1]. Most of the tumors are located in the left atrial.…”

Section: Introductionmentioning

confidence: 99%

The Value of Multi-slice CT Imaging in Cardiac Myxomas in Comparison with Follow-Up Screening in Thoracoscopic Surgery

Hong-jun

Liang

Tan

2015

Cell Biochem Biophys

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“…Cardiac myxoma is the most frequent nonmalignant tumor of the heart, but its incidence is still quite rare, with an incidence of 0.5 per million per annum [1][2][3]. The vast majority (75-83%) occur in the left atrium, a very small percentage (1.3-2.5%) of myxomas are in both atria, most patients are women (56-64%), and embolic symptoms can occur (16-40%) [1][2][3][4].…”

Section: Introductionmentioning

confidence: 95%

“…The vast majority (75-83%) occur in the left atrium, a very small percentage (1.3-2.5%) of myxomas are in both atria, most patients are women (56-64%), and embolic symptoms can occur (16-40%) [1][2][3][4]. To date, the only case of pulmonary embolism occurring in the presence of a left atrial myxoma involved the tumor crossing a large type II atrial septal defect [5].…”

Section: Introductionmentioning

confidence: 95%

Left atrial myxoma presenting as pulmonary embolism

Redford

Thompson²,

McCulloch

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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We present the case of a patient with left atrial myxoma that presented with pulmonary embolism. The patient did not have any intracardiac communication between right and left sides of the heart. Using thrombelastography, the patient was determined to have an abnormally large velocity of plasma thrombus growth and strength with reduced vulnerability to lysis. Critically, increased carboxyhemoglobin concentrations were present, likely secondary to hemolysis from the tumor and engagement of systemic heme oxygenase-1. It was determined that the patient's plasmatic hypercoagulability was in part due to carboxyhemefibrinogen formation via a thrombelastographic method. In addition to circulating hypercoagulability, the patient also had an area of chronic venous stasis in his left ankle that had not changed for over a decade prior to this thrombophilic episode. In conclusion, we present the first case of paradoxical pulmonary embolism in the presence of a left atrial myxoma, potentially secondary to a combination of hemolysis, heme oxygenase-1 up-regulation, systemic hypercoagulability/hypofibrinolysis, and regional venous stasis.

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“…Myxomas can be quite large, occupying most of the left atrium resulting in obstruction to left ventricular filling, while prolapse of a tumor through the mitral valve may result in the destruction of the annulus or valve leaflets causing mitral valve regurgitation [3]. It occurs sporadically in Case Reports in Clinical Medicine all age groups, mostly between the third and sixth decades, and women are more commonly affected than men [4] [5]. Myxomas are slowly growing and usually remain asymptomatic and incidentally discovered in about 20% of cases [6].…”

Section: Introductionmentioning

confidence: 99%

Left Atrial Myxoma in a Woman with Postpartum Heart Failure: The Culprit or an Incidental Bystander

Baba¹,

Talle²,

Buba³

et al. 2018

CRCM

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Myxoma is a benign and the most frequent tumor of the heart, accounting for approximately 30% of all primary cardiac tumors. Seventy five percent of atrial myxomas are in the left atrium. We present a case of a 20-year-old house wife presenting with biventricular heart failure and chest infection five months after her last child birth. Transthoracic echocardiography showed a mobile left atrial echogenic mass measuring 4.6 × 4.0 cm attached to the interatrial septum. Left ventricular systolic function was mildly reduced (EF 48%) with mitral and tricuspid incompetence. A diagnosis of left atrial myxoma with biventricular heart failure with chest infection was made. She improved on antibiotics and treatment of heart failure, and referred to Aminu Kano Teaching Hospital for further management.

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Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Abstract: Background and Purpose: Cardiac myxoma is a major primary heart tumor which often causes unexpected symptoms or sudden death. This present study was designed to investigate its clinical pathological features and biological behavior.

Cited by 39 publications

References 18 publications

The Value of Multi-slice CT Imaging in Cardiac Myxomas in Comparison with Follow-Up Screening in Thoracoscopic Surgery

The Value of Multi-slice CT Imaging in Cardiac Myxomas in Comparison with Follow-Up Screening in Thoracoscopic Surgery

Left atrial myxoma presenting as pulmonary embolism

Left Atrial Myxoma in a Woman with Postpartum Heart Failure: The Culprit or an Incidental Bystander

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