Histopathologic Analysis of Adenoma and Adenoma-related Lesions of the Gallbladder

Abstract

Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently. Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis.

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

“…In this study, we observed these changes in and around tumor area, supporting the first hypothesis. Gall bladder adenomas are relatively rare, few studies are available regarding their carcinogenic potential (Lee et al, 2010). In our study, we reported single case of adenoma ( Figure 1D) and a case of adenocarcinoma in situ, which appeared to arise from a preexisting adenoma.…”

Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?

“…The authors reported dysplasia rates of 2.3% (18/771) with a median age of 45 years in a population with strong Asian ethnicity representation (66%). Our study observed lower rates of dysplastic changes at 1.37% (55/4027) with a higher median age of 53 years, perhaps partly explained by the lack of representation of the Asian population in our study group[21]. …”

“…Cairns et al[24] in 2013 examined a large cohort of gallbladder polyps in a United Kingdom population and observed a similar 2.2% incidence rate of adenomas as well as 0.7% adenocarcinoma rate. Although adenomas are histologically benign, there is a well-recognised adenoma-carcinoma path of carcinogenesis to gallbladder malignancy[21]. This has led to polyp surveillance implementation in HPB centres with indications to operatively remove gallbladders displaying polypoid lesions above 1 cm, rapidly growing in size or symptomatic in nature[24].…”

A rare cause of dilated bile duct incidentally detected on imaging

“…Meanwhile, adenomas of the extrahepatic biliary tree are incredibly sparse and intestinal histology is the commonest 5. Morphologically they are divided into papilloma, tubular adenoma, villous adenoma or tubulovillous adenoma 2 7. Rarely there can be fibromas and neuromas 1.…”