Histones isolated from human parotid fluid

Balekjian, Aram Y.; Longton, Robert W.

doi:10.1016/0006-291x(73)91297-7

Cited by 27 publications

(7 citation statements)

References 10 publications

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“…Several genes-including calmodulin, β-2-microglobulin, epidermal growth factor, ferritin, fibroblast growth factor, heat-shock protein 70, hepatocyte growth factor, histones, interleukin-2, interleukin-6, interleukin-8, superoxide dismutase, etc.-were detected by microarray, but not by proteomic profiling. Other investigators have previously found these proteins to be present in human saliva (Balekjian and Longton, 1973;Law and Henkin, 1986;Maddali et al, 1995;Trubnikov et al, 1998;Kagami et al, 2000;Streckfus et al, 2001;Nagler et al, 2002;Ohshima et al, 2002;Fabian et al, 2003;Eckley et al, 2004). In conclusion, comparative analysis of the saliva proteome and transcriptome from three healthy individuals allowed us to conclude that many salivary proteins and mRNA are concordantly present in human saliva.…”

Section: Discussionsupporting

confidence: 54%

Human Saliva Proteome and Transcriptome

Wang

et al. 2006

J Dent Res

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This paper tests the hypothesis that salivary proteins and their counterpart mRNAs co-exist in human whole saliva. Global profiling of human saliva proteomes and transcriptomes by mass spectrometry (MS) and expression microarray technologies, respectively, revealed many similarities between saliva proteins and mRNAs. Of the function-known proteins identified in saliva, from 61 to 70% were also found present as mRNA transcripts. For genes not detected at both protein and mRNA levels, we made further efforts to determine if the counterpart is present. Of 19 selected genes detected only at the protein level, the mRNAs of 13 (68%) genes were found in saliva by RT-PCR. In contrast, of many mRNAs detected only by microarrays, their protein products were found in saliva, as reported previously by other investigators. The saliva transcriptome may provide preliminary insights into the boundary of the saliva proteome.

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Section: Discussionsupporting

confidence: 54%

Human Saliva Proteome and Transcriptome

Wang

et al. 2006

J Dent Res

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“…A number of investigators have purified so-called "histidine-rich proteins" from human parotid saliva (Balekjian and Longton, 1973;Hay, 1975;Holbrook and Molan, 1975;Baum et al, 1976;MacKay et al, 1984b;Oppenheim et al, 1986). These proteins have been shown to adhere strongly to and inhibit formation of hydroxyapatite (Hay, 1975;Oppenheim et al, 1986).…”

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confidence: 95%

Invited Review: Genetics of Human Salivary Proteins

Minaguchi

Bennick

1989

J Dent Res

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“…Histatins (Hsts) are a family of related cationic histidine-rich polypeptides of variable length found in abundance in the saliva of humans and old-world monkeys [1,2]. The primary structure of the major family members (Hist-1, -3, and -5) has been determined and indicates that these peptides consist of 38, 32, and 24 amino acids, respectively [3,4].…”

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confidence: 99%

Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5

Petruzzelli

Clementi²,

Marini

et al. 2003

Biochemical and Biophysical Research Communications

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Histatin-5 is a peptide secreted in the human saliva, which possesses powerful antifungal activity. Previous studies have shown that this peptide exerts its candidacidal activity, through the inhibition of both mitochondrial respiration and the formation of reactive oxygen species. The purpose of the present study was to investigate the biological consequences of histatin-5 action on mammalian mitochondria to verify if the toxic mechanism exerted on mitochondria from Candida albicans is an exclusive for fungal cells. Moreover, hypothesising that the damage exerted on mitochondria may induce programmed cellular death pathways, we evaluated two main markers of apoptosis: the mitochondrial membrane potential (DW) and the release of cytochrome c. The results obtained show that exposure of isolated mammalian mitochondria to histatin-5 determines: (i) a large inhibition of the respiratory chain at the level of complex I, (ii) a slight decrease in the mitochondrial membrane potential, and (iii) no release of cytochrome c.

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Histones isolated from human parotid fluid

Cited by 27 publications

References 10 publications

Human Saliva Proteome and Transcriptome

Human Saliva Proteome and Transcriptome

Invited Review: Genetics of Human Salivary Proteins

Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5

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