Histone modifications in cocaine, methamphetamine and opioids

Cheng, Jiaoqi; He, Ziping; Chen, Qianqian; Jin, Lin; Peng, Yilin; Zhang, Jinlong; Yan, Xisheng; Yan, Jie; Niu, Shuliang

doi:10.1016/j.heliyon.2023.e16407

Cited by 4 publications

(1 citation statement)

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“…For instance, histone acetyltransferases and histone deacetylases (HDACs) jointly control the addition or deletion of acetyl groups on the histone tails. 132 HDACs could be divided into five major families, including class I (HDACs 1, 2, 3, 8), class IIA (HDACs 4, 5, 7, 9), class IIB (HDAC 6, 10), class III (SIRT1–7) and class IV (HDAC11), and the class I members play a key role in the initiation and progression of depression.…”

Section: Effect Of Gut Microbiota-derived Scfas On Depressionmentioning

confidence: 99%

Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cheng,

Hu,

et al. 2024

Gen Psych

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The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites of the gut microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component of the microbiota-gut-brain axis in depression. In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. Concluding remarks on the biological mechanisms related to gut microbiota will hopefully address the clinical value of microbiota-related treatments for depression.

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Section: Effect Of Gut Microbiota-derived Scfas On Depressionmentioning

confidence: 99%