2018
DOI: 10.3892/or.2018.6295
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Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in�vitro

Abstract: KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. In the present study, we identified that KMT5A was elevated in 50 pairs of papillary thyroid cancer tissue samples and in cell lines K1 and TPC-1 by qRT-PCR and western blotting, as well as by immunohistochemical staining. CCK-8 assay and flow cytometric analysis revealed that inhibition of KMT5A attenuated… Show more

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Cited by 37 publications
(41 citation statements)
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“…Preliminary exploration of lipid metabolism in patients with TC revealed the existence of lipid metabolism disorders (27). The present study demonstrated that ApoA1 and HDL-C levels, which have positive effects in human metabolism, were decreased Conversely, TG level and LDL-C/HDL-C ratio, which Table IV.…”
Section: Discussionsupporting
confidence: 52%
“…Preliminary exploration of lipid metabolism in patients with TC revealed the existence of lipid metabolism disorders (27). The present study demonstrated that ApoA1 and HDL-C levels, which have positive effects in human metabolism, were decreased Conversely, TG level and LDL-C/HDL-C ratio, which Table IV.…”
Section: Discussionsupporting
confidence: 52%
“…Consistent with this, the overexpression of SETD8 has been reported in many different solid tumors [14][15][16][17] and pharmacological inhibition of SETD8 is sufficient to activate the p53 pro-apoptotic program in neuroblastoma cell lines 18 . This has suggested that this enzyme could be an attractive target to rescue p53 functions in cancers displaying a low incidence of p53 genetic alterations, as it is the case at early stages in multiple myeloma 19 .…”
Section: Introductionsupporting
confidence: 70%
“…An up-regulation of SETD8 is not specific to multiple myeloma, as it has also been observed in different types of solid tumors 11 , such as papillary thyroid cancer 16 , breast carcinoma 14,26 , and childhood tumors of the nervous system 15,18 . However, the mechanisms that contribute to elevated levels of SETD8 in cancer still remained unclear.…”
Section: Pharmacological Inhibition Of Setd8 Synergizes With Melphalamentioning
confidence: 99%
“…SET8 is functional in multiple cellular pathways, such as DNA replication, chromosome compaction, cell cycle progression, transcriptional modulation, genomic instability, and cellular metabolism [17][18][19][20]. Moreover, SET8 is involved in cancer proliferation, invasiveness, and migration and is thus associated with a poor survival rate in cancer patients [21,22]. Some reports show that high methyltransferase activity of SET8 is associated with a high recurrence rate and poor overall survival rate in patients with liver cancer [23].…”
Section: Introductionmentioning
confidence: 99%