Histone Deacetylases Enzyme, Copper, and IL-8 Levels in Patients With Alzheimer’s Disease

Alsadany, Mohamad; Shehata, Hanan H.; Mohamad, Magda I.; Mahfouz, Riham

doi:10.1177/1533317512467680

Cited by 66 publications

(41 citation statements)

References 46 publications

(76 reference statements)

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“…IL-8 has been known to initiate acute inflammation, and our data support the involvement of elevated IL-8 in the chronic neuroinflammation of AD which may be related to cerebrovascular damage [30]. Actually, significant elevations in plasma IL-8 levels in cognitive impairment have also been reported by others [5,13], although there are also conflicting data showing lower IL-8 level in mild cognitive impairment and AD [31]. The mechanism underlying associations of IL-8 with WMH is at present unclear.…”

Section: Discussionsupporting

confidence: 88%

Serum IL‐8 is a marker of white‐matter hyperintensities in patients with Alzheimer's disease

Zhu

Chai

Hilal

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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IntroductionNeuroinflammation and cerebrovascular disease (CeVD) have been implicated in cognitive impairment and Alzheimer's disease (AD). The present study aimed to examine serum inflammatory markers in preclinical stages of dementia and in AD, as well as to investigate their associations with concomitant CeVD.MethodsWe performed a cross-sectional case–control study including 96 AD, 140 cognitively impaired no dementia (CIND), and 79 noncognitively impaired participants. All subjects underwent neuropsychological and neuroimaging assessments, as well as collection of blood samples for measurements of serum samples interleukin (IL)-6, IL-8, and tumor necrosis factor α levels. Subjects were classified as CIND or dementia based on clinical criteria. Significant CeVD, including white-matter hyperintensities (WMHs), lacunes, and cortical infarcts, was assessed by magnetic resonance imaging.ResultsAfter controlling for covariates, higher concentrations of IL-8, but not the other measured cytokines, were associated with both CIND and AD only in the presence of significant CeVD (CIND with CeVD: odds ratios [ORs] 4.53; 95% confidence interval [CI] 1.5–13.4 and AD with CeVD: OR 7.26; 95% CI 1.2–43.3). Subsequent multivariate analyses showed that among the types of CeVD assessed, only WMH was associated with higher IL-8 levels in CIND and AD (WMH: OR 2.81; 95% CI 1.4–5.6).DiscussionSerum IL-8 may have clinical utility as a biomarker for WMH in AD. Longitudinal follow-up studies would help validate these findings.

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Section: Discussionsupporting

confidence: 88%

Serum IL‐8 is a marker of white‐matter hyperintensities in patients with Alzheimer's disease

Zhu

Chai

Hilal

et al. 2017

Alz & Dem Diag Ass & Dis Mo

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“…Changes in levels of IL-6, IL-8, IL-12, and TNFα have been reported. Similar changes are observed in AD (Singh and Guthikonda, 1997; Swardfager et al, 2010; Cojocaru et al, 2011; Alsadany et al, 2013). While a lack of data exists regarding MyD88 in human AD patients, in one AD mouse model genetic ablation of MyD88 was found to mitigate microglial activation and amyloid beta toxicity (Lim et al, 2011).…”

Section: Sterile Inflammationsupporting

confidence: 64%

Bioenergetic Dysfunction and Inflammation in Alzheimerâ€™s Disease: A Possible Connection

Wilkins

Carl

Greenlief

et al. 2014

Front. Aging Neurosci.

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Inflammation is observed in Alzheimer’s disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no “foreign” agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed.

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“…The results showed that levels of IL-8 and monocyte chemo-attractant protein 1 (MCP-1) were significantly increased in brain tissue derived from AD patients relative to controls. A more recent work has also reported that levels of IL-8 were considerably elevated in AD patients compared to non-demented controls [12]. Importantly, the increased levels of IL-8 showed a correlation with a reduced performance on cell cognition tasks.…”

Section: Introductionmentioning

confidence: 84%

Chemokine Interleukin-8 (IL-8) in Alzheimer’s and Other Neurodegenerative Diseases

McLarnon¹

2016

J Alzheimers Dis Parkinsonism

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Histone Deacetylases Enzyme, Copper, and IL-8 Levels in Patients With Alzheimer’s Disease

Abstract: Plasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.

Cited by 66 publications

References 46 publications

Serum IL‐8 is a marker of white‐matter hyperintensities in patients with Alzheimer's disease

Serum IL‐8 is a marker of white‐matter hyperintensities in patients with Alzheimer's disease

Bioenergetic Dysfunction and Inflammation in Alzheimerâ€™s Disease: A Possible Connection

Chemokine Interleukin-8 (IL-8) in Alzheimer’s and Other Neurodegenerative Diseases

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