Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells

Sobolewski, Cyril; Sanduja, Sandhya; Blanco, Fernando F.; Hu, Liangyan; Dixon, Dan A.

doi:10.3390/biom5032035

Cited by 33 publications

(42 citation statements)

References 54 publications

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“…These results are in accord with those performed in the Myc-driven B cell lymphoma mouse model where enforced TTP expression in B cells disables the maintenance of lymphomas in syngeneic transplant model [5]. Interestingly, a recent study reported links of histone deacetylase inhibitor (HDACi) activity to TTP, where treatment of colorectal cancer cells with HDACi activates the EGR1 transcription factor to induce TTP and provoke growth arrest [19]. Collectively, these findings suggest that developing new therapeutics that specifically stimulate TTP expression may be an avenue for treating patients with low-TTP expressing tumors.…”

Section: Discussionsupporting

confidence: 84%

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function

et al. 2016

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Tristetraprolin (TTP) is an RNA-binding protein that post-transcriptionally suppresses gene expression by delivering mRNA cargo to processing bodies (P-bodies) where the mRNA is degraded. TTP functions as a tumor suppressor in a mouse model of B cell lymphoma, and in some human malignancies low TTP expression correlates with reduced survival. Here we report important prognostic and functional roles for TTP in human prostate cancer. First, gene expression analysis of prostate tumors revealed low TTP expression correlates with patients having high-risk Gleason scores and increased biochemical recurrence. Second, in prostate cancer cells with low levels of endogenous TTP, inducible TTP expression inhibits their growth and proliferation, as well as their clonogenic growth. Third, TTP functions as a tumor suppressor in prostate cancer, as forced TTP expression markedly impairs the tumorigenic potential of prostate cancer cells in a mouse xenograft model. Finally, pathway analysis of gene expression data suggested metabolism is altered by TTP expression in prostate tumor cells, and metabolic analyses revealed that such processes are impaired by TTP, including mitochondrial respiration. Collectively, these findings suggest that TTP is an important prognostic indicator for prostate cancer, and augmenting TTP function would effectively disable the metabolism and proliferation of aggressive prostate tumors.

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Section: Discussionsupporting

confidence: 84%

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function

et al. 2016

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“…Another article revealed that the down-regulation of EGR1-p21 expression provides a mechanism for improved hematopoiesis (89). Histone deacetylase (HDAC) inhibitors can reactivate EGR1 in various cell types, leading to decreased cell proliferation and increased cell apoptosis (90). HDAC recruitment may participate in the repressive mechanism that EGR1 directly represses myocyte enhancer factor 2 (MEF2) activity for treatment of cardiac disease (91).…”

Section: Pathogenesis Mechanism Of Aml By Egr1mentioning

confidence: 99%

The progress of early growth response factor 1 and leukemia

Tian

Han

Jiang

et al. 2016

IRDR

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“…Cancer has a high morbidity and mortality[1-4]. In China, with the improvement of the economy and the enormous change in lifestyle and eating habits, the morbidity and mortality of gastric cancer have increased annually.…”

Section: Introductionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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AIMTo explore expression of angiopoietin-like protein 2 (ANGPTL2) and its effect on biological behavior such as proliferation and invasiveness in gastric cancer.METHODSWestern blotting was used to detect expression of ANGPTL2 in 60 human normal gastric tissues, 60 human gastric cancer tissues and gastric cell lines including GES-1, N87, SGC7901, BGC823 and PAMC82. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Transwell assay were used to detect the proliferation and invasive ability of gastric cancer cells.RESULTSCompared to normal tissues, ANGPTL2 protein levels were significantly upregulated in gastric tissues, and this level was closely correlated with gastric tumor grade, clinical stage and lymph node metastasis. Compared to GES-1 cells, ANGPTL2 mRNA and protein levels were significantly increased in gastric cancer cells including N87, SGC7901, BGC823 and PAMC82. The expression of ANGPTL2 in highly malignant gastric cancer cell lines BGC823 and PAMC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901. MTT and Transwell experiments indicated that the proliferation rate and invasive ability of stable overexpressed gastric cancer cells was faster than in cells transfected with Lv-NC and blank control cells, and the invasive ability of stable overexpressed gastric cancer cells was higher than that of cells transfected with Lv-NC and blank control cells.CONCLUSIONANGPTL2 contributed to proliferation and invasion of gastric cancer cells. In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.

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Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells

Cited by 33 publications

References 54 publications

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function

Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function

The progress of early growth response factor 1 and leukemia

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

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