Histomorphometric Evaluation of Titanium Implants in Osteoporotic Rabbits

Gg, Lugero; Caparbo, de Falco; Ml, Guzzo; König, Bruno; Jorgetti,

doi:10.1097/00008505-200009040-00005

Cited by 79 publications

(62 citation statements)

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“…This finding is consistent with several other studies [30][31][32] and suggests that osseointegration of implants may be compromised in patients with primary osteopenia, osteoporosis or secondary osteoporosis, for instance due to rheumatoid arthritis or prolonged corticosteroid treatment. There were no statistical effects of OVX on the osseointegration of titanium-only implants.…”

Section: Discussionsupporting

confidence: 93%

Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Eberhardt

Stumpf²,

Kurth

2005

Eur J Trauma

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European Journal of TraumaAb stract Background and Purpose: Cementless total joint replacement in osteopenic bone is suspected to deteriorate long-term survival of implants because results in dental implantology research indicate that bone ingrowth of dental implants in osteoporotic bone is impaired. The present investigation was designed to determine whether osteopenic bone stock, experimentally created in ovariectomized rats, influences the active bone-implant integration process. Material and Methods: 40 Sprague-Dawley rats were randomly assigned to two treatment groups; one group underwent ovariectomy, the other sham ovariectomy. Successful development of osteopenia was assessed by bone mineral density measurement of the lumbar vertebra L5 before implant surgery and before sacrifice. An uncoated and a hydroxyapatite-coated titanium implant were surgically inserted into the medullary canal of each femur. After 28 days specimens were prepared for histomorphometry to determine the osseointegrated implant surface. Results:The results showed a successful development of experimentally induced osteopenia in ovariectomized rats. For hydroxyapatite-coated implants the histomorphometry revealed a mean osseointegrated implant surface of 54.5% in the sham group versus 23.7% in the ovariectomy group. There was no significant difference for uncoated titanium implants. Conclusion: The present study in rats clearly demonstrates that osteopenic bone loss induced by ovariectomy impairs bone-implant ingrowth of hydroxyapatite-coated implants in the metaphysis of the femur. This is a potential risk for deterioration of long-term outcome of cementless metal implants in osteopenic bone. In consequence, the quality of bone stock has to be taken into account while making a decision for cemented or cementless joint replacements.

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Section: Discussionsupporting

confidence: 93%

Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Eberhardt

Stumpf²,

Kurth

2005

Eur J Trauma

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“…The authors noted poor interaction between the material implanted and bone tissue, as well as a low amount of newly formed bone, and attributed the findings to the osteoporosis-like conditions as a result of gonadal deficiency induced by ovariectomy (Hayashi et al, 1994;Lugero et al, 2000). Similar results have been reported by De Benedittis et al, (1999);Fini et al, (1997); Hayashi et al, (1994);Jung et al, (2001);and Pan et al, (2000), who used hydroxyapatite as implant material.…”

Section: Discussionsupporting

confidence: 59%

“…The histological findings presented a poor interaction between the inserted material and bone tissue, and a low amount of newly formed bone, and were attributed to the osteoporosis-like conditions as a result of gonadal deficiency induced by ovariectomization procedure (Li et al, 2004;Lugero et al, 2000;Pan et al, 2000;Wang et al, 2005). Similar findings have also been reported by De Benedittis et al (1999), Fini et al (1997), Hayashi et al (1994);Jung et al (2001), who, however, used hydroxyapatite as implant material.…”

Section: Discussionmentioning

confidence: 99%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

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“…Estrogen deficiency is not a contraindication for the use of dental implants, requiring a longer waiting period for osseointegration. The same applies for grafts, since the osteopenic condition probably inhibits new bone formation 3,6,9 . In the present study, considering the bone formed around the grafts in the medullary region, the only difference between oophorectomized and non-oophorectomized animals was that the quantity of bone was lower in the first group.…”

Section: Discussionmentioning

confidence: 97%

New bone formation in the female rabbit tibia

2004

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The current study aims to evaluate the new bone formation in polyvinylpyrrolidone (PVP) grafts inserted into the tibia of ten female rabbits. The animals were submitted to oophorectomy in order to induce an osteopenic condition and densitometrically analyzed at the beginning of the experiment, at three months and at seven months. During the 16 weeks of osseointegration, the animals were submitted to subcutaneous injections of three bone markers at one-week intervals, four weeks for each. Before the third densitometric analysis, the animals were sacrificed and material was collected for histological evaluation, in which osteoid formations and mineralized bone tissue were observed surrounding the grafts, even within the medullary cavity. Only small quantities of new bone were found in the osteopenic animals, indicating the high osteocondutivity of PVP and its efficacy in inducing osteopenia. Among the samples with no graft, a high level of disorganization of the material was observed in the oophorectomized group, confirming the efficacy of oophorectomy.

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Histomorphometric Evaluation of Titanium Implants in Osteoporotic Rabbits

Cited by 79 publications

References 0 publications

Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

New bone formation in the female rabbit tibia

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