Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Eberhardt, Christian; Stumpf, U.; Kurth, Andreas

doi:10.1007/s00068-005-1443-z

Cited by 2 publications

(4 citation statements)

References 36 publications

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“…The implants were inserted mainly into the rat tibia (65.85%) or in the femur (19.5%). In 1 study, implants were placed into the medullary canal of the femur, in 3 studies, they were placed into healed post‐extraction sockets and in 1 into the maxillary arch …”

Section: Resultsmentioning

confidence: 99%

“…32 The implants were inserted mainly into the rat tibia (65.85%) or in the femur (19.5%). In 1 study, implants were placed into the medullary canal of the femur, 33 in 3 studies, they were placed into healed post-extraction sockets 29,34,35 and in 1 into the maxillary arch. 36 Rabbits were used in 10 studies (17.54%) and in 60% of these studies, the age of the animals was between 4 and 12 months.…”

Section: Animal Modelsmentioning

confidence: 99%

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Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Dereka

Calciolari

Donos

et al. 2018

J of Periodontal Research

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Osteoporosis is one of the most common skeletal disorders affecting a significant percentage of people worldwide. Research data suggested that systemic diseases such as osteoporosis could act as risk factors for osseointegration, jeopardizing the healing process and thus the predictability of dental implant success on compromised patients. It is well accepted that preclinical studies in animal models reproducing the osteoporotic condition are one of the most important stages in the research of new biomaterials and therapeutic modalities. The aim of this systematic review was to investigate whether osteoporosis compromises dental implant osseointegration in experimental osteoporotic-like conditions. A 3-stage systematic literature research was conducted in MEDLINE via OVID and EMBASE up to and including March 2017. Experimental studies reporting on dental implant osseointegration on different osteoporotic animal models were assessed. The studies had to report on the percentage of bone-to-implant contact (%BIC) as the primary outcome. ARRIVE guidelines for reporting on animal research were applied to evaluate the methodological quality and risk of bias of the studies. Fifty-seven studies met the inclusion criteria and were assessed qualitatively. The most adopted animal model was the rat. A variability of %BIC values was observed, ranging from 30% to 99% and from 26% to 94% for the healthy and osteoporotic group, respectively. The great majority (47) of the included studies concluded that estrogen deficiency significantly affects BIC values, 9 studies stated that it was not possible to observe statistical differences in BIC between ovariectomized and healthy groups and 1 study did not provide a comparison between the healthy and osteoporotic group. Owing to the great heterogeneity in implant surface, study design, observation time-points, site of implant placement and reported outcomes, a meta-analysis could not be performed. An overall high risk of bias was observed, owing to the limited information on animal housing and husbandry, baseline characteristics and health status, ethical statement and allocation to the experimental groups provided. Although the available studies seem to suggest a lower osseointegration in osteoporotic-like conditions, no robust conclusions can be drawn due to the great heterogeneity and overall low quality of the available studies. Future studies with emphasis on minimizing the possible sources of bias and evaluating osseointegration of dental implants placed into jawbones instead of long bones are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Dereka

Calciolari

Donos

et al. 2018

J of Periodontal Research

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“…It was noted that implants immersed with bisphosphonates were synthesised using titanium alloys and coated with hydroxyapatite before immersion. However, the effect of hydroxyapatite coating was reported to deteriorate bone-implant ingrowth in osteoporotic patients [32,33]. Although they reported that there are undesired effects of hydroxyapatite, their study groups were coated before immersion.…”

Section: Discussionmentioning

confidence: 99%

“…Gao et al [32] stated that the benefit of bisphosphonate immersion on the implant surface is that they impact osteoclasts by eradicating their proliferation activity, which is desirable for patients with osteoporosis. Another study suggested that the use of hydroxyapatite-coated implants enhances bone mineralisation, formation, and mechanical stability; however, using such implants may lead to loosening and inflammation in the implant site due to the damage it causes to the bone matrix [33].…”

Section: Implant Surface Nanotopographymentioning

confidence: 99%

A Review of Conventional and Novel Treatments for Osteoporotic Hip Replacements

et al. 2023

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Introduction: Osteoporosis is a skeletal disease that severely affects the mechanical properties of bone. It increases the porosity of cancellous bone and reduces the resistance to fractures. It has been reported in 2009 that there are approximately 500 million osteoporotic patients worldwide. Patients who suffer fractures due to fragility cost the National Healthcare Systems in the United Kingdom £4.4 billion in 2018, in Europe €56 billion in 2019, and in the United States $57 billion in 2018. Thus, osteoporosis is problematic for both patients and healthcare systems. Aim: This review is conducted for the purpose of presenting and discussing all articles introducing or investigating treatment solutions for osteoporotic patients undergoing total hip replacement. Methods: Searches were implemented using three databases, namely Scopus, PubMed, and Web of Science to extract all relevant articles. Predetermined eligibility criteria were used to exclude articles out of the scope of the study. Results: 29 articles out of 183 articles were included in this review. These articles were organised into three sections: (i) biomechanical properties and structure of osteoporotic bones, (ii) hip implant optimisations, and (iii) drug, cells, and bio-activators delivery through hydrogels. Discussion: The findings of this review suggest that diagnostic tools and measurements are crucial for understanding the characteristics of osteoporosis in general and for setting patient-specific treatment plans. It was also found that attempts to overcome complications associated with osteoporosis included design optimisation of the hip implant; however, only short-term success was reported, while the long-term stability of implants was compromised by the progressive nature of osteoporosis. Finally, it was also found that targeting implantation sites with cells, drugs, and growth factors has been outworked using hydrogels, where promising results have been reported regarding enhanced osteointegration and inhibited bacterial and osteoclastic activities. Conclusions: These results may encourage investigations that explore the effects of these impregnated hydrogels on osteoporotic bones beyond metallic scaffolds and implants.

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Simulated Osteopenia Impairs Metaphyseal Bone Ingrowth of Metal Implants in an Animal Model

Cited by 2 publications

References 36 publications

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

Osseointegration in osteoporotic‐like condition: A systematic review of preclinical studies

A Review of Conventional and Novel Treatments for Osteoporotic Hip Replacements

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