Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits

Association between bisphosphonates and jaw osteonecrosis: A study in Wistar rats

“…This result is in accordance with Landesberg et al 23 who argued that the antiangiogenic effect of bisphosphonates in vivo was not yet proven. Pampu et al, 51 in turn, observed an increase and not a decrease in the blood vessels in the bone tissue of rabbits treated with zoledronic acid, in a histomorphometric study with hematoxylin-eosin staining.…”

Comparison of local and systemic alendronate on distraction osteogenesis

“…They interfere with the mevalonate pathway through the inhibition of the farnesyl pyrophosphate synthase enzyme 11,20 . The main pharmacodynamic effect of bisphosphonates is the inhibition of osteoclastic bone resorption, but it is also capable of interacting with osteoblasts.…”

“…Although this technique is used to treat several abnormalities of hard and soft tissues, there are some drawbacks especially related to long-term consolidation periods 20 . For that reason, in the present study, numerous approaches were researched to accelerate the maturation of the regenerate bone including growth factors 15 , hormones 12,23 , calcium sulphate 2 , and electronic 10 and ultrasonic 22 stimulation.…”

“…For that reason, in the present study, numerous approaches were researched to accelerate the maturation of the regenerate bone including growth factors 15 , hormones 12,23 , calcium sulphate 2 , and electronic 10 and ultrasonic 22 stimulation. In recent studies, bisphosphonates 8,20,24 were indicated to be efficient in hastening bone regeneration.…”

Bisphosphonate-related osteonecrosis of jaws in advanced stage breast cancer was detected from bone scan: a case report

“…Islands of woven bone contained plump osteoblasts while osteoclastic activity was absent in such areas. These features suggest that BPs likely act by stimulating appositional osteogenesis without concurrent remodeling or resorption of pre-existing bone trabeculae (16)(17)(18)(19)(20). Areas of active acute inflammation contained abundant osteoclast-like cells at the interface with residual bone spiculae and were filled with an inflammatory infiltrate, mostly composed by polymorphonuclear phagocytes, plasma cells, monocytes and lymphocytes, acellular necrotic debris, thin-walled and dilated blood vessels and scattered residual and intensely basophilic bone spiculae.…”