Association between bisphosphonates and jaw osteonecrosis: A study in Wistar rats

Maahs, Marcia P.; Azambuja, Alan A.; Campos, Maria M.; Salum, Fernanda Gonçalves; Cherubini, Karen

doi:10.1002/hed.21422

Cited by 69 publications

(102 citation statements)

References 44 publications

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“…BRONJ is more common in the posterior mandible than the maxilla, in a ratio of 2: 1 (33) and it is related to dental extraction (20,34), trauma to the mouth caused by incorrectly adjusted prostheses (35), oral infection (36), poor oral hygiene (37),dentoalveolar procedures on the bone (38), diabetes and smoking (20,39).…”

Section: Discussionmentioning

confidence: 99%

Bisphosphonate-Related Osteonecrosis of the Jaws: a real Challenge for Dentists

Ioana-Auriţa

Petrovan

Cuc

et al. 2015

Acta Medica Marisiensis

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Background: Osteonecrosis of the jaw is a serious complication associated with oral and intravenous bisphosphonate therapy. Its pathogenesis is not well understood and its management is difficult.The aim of ourstudy was to evaluate the awareness of dentists in Târgu Mureș on the possibilities of treating patients who are treated with bisphosphonate in dental offices. Material and method: We carried out a questionnaire-based study among dentists in Târgu Mureș reaching important issues such as: if the patient is asked if medical history follows / followed treatment with bisphosphonates, if they made surgical treatment in these patients, if they know under what conditions can they perform this treatment, if they deem it is necessary to contact the prescriber before surgical treatment. Results: Seventy questionnaires were returned. During the medical history most clinicians (60%) asked the patients whether they follow/followed treatment with bisphosphonates and most of them (42.85%) did not perform treatments in these patients. While 85.71% of respondents declared that they do contact the prescriber before performing surgical treatment, 48,57% were not aware under what conditions they could undergone the treatment. Conclusions: The dentists did not seem to be well informed about this pathological entity, known only since 2003. In the absence of appropriate protocols they could not provide a high quality treatment and in these circumstances they might do more harm than good.

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Section: Discussionmentioning

confidence: 99%

Bisphosphonate-Related Osteonecrosis of the Jaws: a real Challenge for Dentists

Ioana-Auriţa

Petrovan

Cuc

et al. 2015

Acta Medica Marisiensis

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“…Research studies concerning the relationship between the repair and the possible factors that affect the healing process after tooth extraction in rats were initiated in early 1923 [10][11] . The healing process post dental extraction has been studied in several animal models, and its sequence is relatively understood and divided into Membranes that are rich in monounsaturated fatty acids (MUFA)…”

Section: Discussionmentioning

confidence: 99%

Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

Melo

Guimarães²,

Silva³

et al. 2014

Acta Cir. Bras.

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Brazil. Conception, design, intellectual and scientific content of the study; critical analysis, final approval of the manuscript. ABSTRACT PURPOSE:To evaluate the antioxidant and antiperoxidative effects of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 in the third day after tooth extraction in rats. METHODS:Thirty-two male Wistar rats (270-310g) were randomly distributed in two groups: Control (n=24) and Test (n=8). Control group was divided into three subgroups (n=8): G1: Sham-Saline; G2: Saline; G3: Isolipid. G1 and G2 animals received NaCl 0.9% while G3 rats were treated with an isolipid mixture (alpha-linolenic acid -ALA) containing -6/-3 oils (8:1 ratio) and-9/-6 (0.4:1 ratio). Test group animals (G4) received oily mixtures (alpha-linolenic acid -ALA, docosahexaenoic acid -DHA, eicosapentaenoic acid -EPA) of -6/-3 (1.4:1 ratio) and -9/-6 (3.4:1 ratio). Saline and oils were administered by gavage during four days before and three days after first mandibular molar extraction. Following, samples (arterial blood and alveolar mucosa) were collected for glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) assays. RESULTS:Oil mixes induced a significant decrease in GSH and TBARS tissue and plasma concentrations in the third day post-surgery. CONCLUSION:Gavage administration of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats induces a significant decrease in lipid peroxidation.

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“…Sonis et al (13) used a dose of 7.5 µg/kg, whereas Pautke et al (19) used the dose of 0.05 mg/kg of zoledronic acid in minipigs. In this study, we used the dose of 0.15 mg/ kg/ week based on the dose of 0.6 mg/kg/28 days used by Maahs et al (23). Although it can be considered a high dose, its use has been safety demonstrated in these previous studies and it was chosen to increase the probability of BRONJ in the studied animals.…”

Section: G8mentioning

confidence: 99%

Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis

et al. 2017

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The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws.

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Association between bisphosphonates and jaw osteonecrosis: A study in Wistar rats

Cited by 69 publications

References 44 publications

Bisphosphonate-Related Osteonecrosis of the Jaws: a real Challenge for Dentists

Bisphosphonate-Related Osteonecrosis of the Jaws: a real Challenge for Dentists

Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis

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