Histomorphometric Estimation of Air Cell Development in Experimental Otitis Media

Abstract

A single incident of otitis media introduced early in life is sufficient to significantly reduce the final volume of the bulla in rats. This finding may mimic the effect of otitis media contracted in early childhood on the development of the mastoid air cells. The standard growth plot provides a timeframe for studies of signaling molecules responsible for bone modeling in pneumatization.

New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures

“…Histomorphometric quantification of tissue composition within the heterogeneous calluses was done using stereology principles [35][36][37] on an Olympus CAST system with Visiopharm software. This technique correlates well with mCT for determining bone volume, 38 but also enables us to quantify soft tissues in the fracture callus.…”

The Possible Associations of Septal Deviation on Mastoid Pneumatization and Chronic Otitis

“…Radiographically mastoid air cells become visible after birth. Hypopneumatized mastoid system has been found to be a risk factor for the development of various middle ear diseases (7). The development of complete adult pneumatization can be divided into 3 stages: the infantile period, which extends from birth to 2 years of age; the transitional period, from 2 to 5 years; and thereafter, the adult period (2,3).…”

A Morphogenetic Model of Cranial Pneumatization Based on the Invasive Tissue Hypothesis

“…The ontogeny of sinuses and air cells has been studied intensively from a clinical perspective, in humans as well as model animals (Ruf and Pancherz, 1996; Weiglein, 1999; Shah et al, 2003; Tan et al, 2003; Mey et al, 2006), and various studies are now available that document sinus growth in nonhuman primates such as Pongo and Macaca (Koppe et al, 1995; Koppe and Nagai, 1997). However, beyond issues concerning growth and allometry of sinus volumes (i.e., size), relatively little is known about how their often complex and highly variable shape is formed during development, and only few studies attempt to quantify sinus morphology beyond volume measurements and description of anatomical variants (Krennmair et al, 1999; Farke, 2007).…”