Histomorphometric analysis of fracture healing cascade in acute osteoporotic vertebral body fractures

Diamond, Terrence; Clark, William; Kumar, Shejil

doi:10.1016/j.bone.2006.10.009

Cited by 48 publications

(52 citation statements)

References 21 publications

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“…In human distal radius fractures, we found osteoid as early as the second week after fracture (Fig 3) [5]. Similarly fast ossification in distal radial fractures has been reported by others [6,7] and studies in human vertebrae and animal models show similar phenomena [8,9].…”

Section: Healing In Cancellous Bone Is Fast and Locally Constrainedsupporting

confidence: 61%

Metaphyseal Fracture Healing

Sandberg¹

2016

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Section: Healing In Cancellous Bone Is Fast and Locally Constrainedsupporting

confidence: 61%

Metaphyseal Fracture Healing

Sandberg¹

2016

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“…In the majority of biopsy specimens, trabecular bone with fibrosis and granulation tissue reflected the various stages of progressive fracture healing. Diamond et al (18) characterized the histological process of fracture healing in cancellous bone of vertebral body and divided this process into four stages. Stage 1 included necrosis and granulation tissue; stage 2 included chondrogenesis and bone matrix synthesis; stage 3 included endochondral ossification and woven bone formation; and stage 4 included bone remodeling and modeling.…”

Section: Discussionmentioning

confidence: 99%

Histological evaluation of bone biopsy results during PVP or PKP of vertebral compression fractures

Zhang¹,

LI²,

Yang³

et al. 2012

Oncology Letters

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Abstract. Percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) is utilized for the treatment of vertebral compression fractures (VCFswith a history of malignancy, malignancy was identified in 25 patients, while osteoporosis was identified in 16 patients. Biopsies of the other 3 patients were not suitable for pathological examination. There were only 2 patients with previously undiagnosed malignancy. One patient was diagnosed with multiple myeloma, while another patient was diagnosed with metastatic carcinoma. In the present study, the rate of unsuspected malignancy was 0.4%. No symptomatic complications occurred as a result of biopsy. The results indicate that biopsy is safely performed during PVP or PKP and it is an efficacious procedure that verifies the pathological process and assists in identifying previously unsuspected processes responsible for VCFs. We recommend obtaining the biopsy of every collapsed vertebral body during PVP or PKP procedures.

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“…15). Hyperosteoidosis/Osteosclerosis (excessive formation of osteoid) is also observed experimentally at comparable time-points (Diamond et al, 2007). Finally remodeling of the cancellous bone architecture is predicted.…”

mentioning

confidence: 59%

“…Therefore this study has only considered the original injury event. In reality, histological analyses (Diamond et al, 2007) revealed that a typical feature of vertebral fractures is the overlap between the different tissues corresponding to the different temporal stages of the fracture healing process. This can be justified with the argument that in vertebral bodies the fracture stabilization that permits orderly repair in long bones is not possible due to repetitive injury.…”

Section: Discussionmentioning

confidence: 99%

“…The spatial and temporal patterns of tissue differentiation predicted by this model are in general agreement with those observed experimentally. Diamond et al, (Diamond et al, 2007) describe 4 stages of fracture healing process in the vertebral body, with significant overlap between the various stages of healing. Chondrogenesis was evident in the second stage of the fracture healing process, which followed the initial granulation tissue stage.…”

mentioning

confidence: 99%

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