Histology changes of in vivo human skin after treatment with fractional 1064 nm Nd:YAG picosecond laser in different energy settings

Chang, Yin Yi; Yang, Ting; Li, Chien Nien

doi:10.1007/s10103-021-03396-w

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…The number and size of LIOBs in the epidermis appears to be correlated with the fluence and the number of passes, according to a study by Chang [7]. Similarly, another study showed that the size and number of LIOBs in the epidermis increased as the fluence or the amount of melanin in the skin increased.…”

Section: Histological Characteristics and Mechanismsmentioning

confidence: 91%

“…These arrays allow the energy to be concentrated within laser microbeams, while neighboring tissue between the microspots is unharmed [2]. Commercially available fractional optical delivery technologies include, diffractive lens arrays (DLA), micro-lens arrays (MLA), and holographic optical arrays [7]. Different optical arrays with different spot sizes have been applied in various picosecond laser devices.…”

Section: Introductionmentioning

confidence: 99%

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An update on fractional picosecond laser treatment: histology and clinical applications

2023

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Picosecond lasers have a very short pulse duration and a high peak power density. When fractional optical delivery systems are attached to picosecond lasers, they generate an array of concentrated microspots with a high fluence surrounded by areas with a low fluence. This article discusses the histologic characteristics and clinical applications of fractional picosecond laser treatment. Fractional picosecond laser produces laser-induced optical breakdown (LIOB) and laser-induced cavitation (LIC) in the epidermis and dermis respectively, and can encourage skin regeneration and dermal remodeling. It has been shown that fractional picosecond laser has a positive effect on facial photoaging, enlarged facial pores, dyspigmentation, wrinkles, and atrophic scars. Further research is still needed to confirm the benefits of fractional picosecond lasers.

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Section: Histological Characteristics and Mechanismsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

An update on fractional picosecond laser treatment: histology and clinical applications

2023

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“…A very typical side effect of FPNYL treatment was the emergence of whiteheads and pruritus in varying degrees over the course of 3–7 days. This may be understood by the histology discovery of vacuoles after therapy in the sebaceous glands and hair follicles 20 …”

Section: Discussionmentioning

confidence: 99%

“…This may be understood by the histology discovery of vacuoles after therapy in the sebaceous glands and hair follicles. 20…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the safety and efficacy of a fractional picosecond 1064 nm laser for post‐acne erythema in adult Chinese patients

Jia

Zheng

Lin

et al. 2023

Skin Research and Technology

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Objective To evaluate the efficacy and safety of fractional 1064 nm picosecond Nd:YAG laser (FPNYL) in the treatment of post‐acne erythema (PAE) of adult Chinese. Materials and methods A total of 22 patients received 1 session of treatment and were followed up at the eighth week. Primary outcomes were measured by the Clinician erythema assessment scale (CEAS). Secondary outcomes included a global aesthetic improvement scale (GAIS) and patients’ assessment of satisfaction on a five‐point scale. Pain scores and adverse effects were also evaluated. Results Twenty‐two patients with Fitzpatrick skin types III and IV were enrolled in the study and completed all treatments and follow‐up visits. The mean CEAS scores fell from 2.74 ± 0.80 to 1.95 ± 0.75 (p < 0.05). The mean GAIS of PAE improvement was 2.46 ± 0.68. Erythema percentile scores by VISIA increased from 32.63 ± 7.0 to 45.75 ± 11.45 (t = 5.442, p = 0). The patient satisfaction score was 1.86 ± 1.17. The pain scores were 3.27 ± 1.17 for the FPNYL treatment (varied from 2 to 6). There were moderate erythema and oedema, which last for 3.84 ± 0.78 days. There were overall 68.18% (15/22) patients who felt pruritus in different degrees and 27.27% patients who encountered acne eruptions (white head type). No scar, hyperpigmentation or hypopigmentation was found. Conclusion Treatment with fractional 1064 nm picosecond Nd:YAG laser is effective and safe for PAE of Chinese patients.

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“…The LIOB area corresponded to the distribution of the micro‐lens in the arrays. In addition, a previous histologic study reported that laser‐induced cavitation (LIC) and red blood cell extravasation in the superficial dermis were noted across specimens with stacking pulses from a fractional 1064 nm Nd:YAG picosecond laser 22 . This photomechanical stress in the epidermis and dermis and the focal damage to keratinocytes by the fractional picosecond laser stimulates the release of cytokines and chemokines, creating an environmental milieu that is conducive to wound healing, neocollagenosis, neoelastogenesis, and the reduction of elastic fragmentation 23,24 …”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of fractional 1064‐nm picosecond laser for atrophic traumatic and surgical scars: A randomized, single‐blinded, split‐scar‐controlled study

et al. 2023

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Objective: A fractional 1064-nm picosecond laser is an efficient and safe treatment for atrophic acne scars. However, evidence of using a picosecond laser for atrophic posttraumatic and surgical scar therapy is lacking. This study aimed to evaluate the efficacy and safety of using a 1064-nm picosecond laser with a microlens array (MLA) for the treatment of atrophic posttraumatic and surgical scars. Methods: This was a prospective, intraindividual, single-blinded, randomized split-lesion-controlled trial. Twenty-five subjects with atrophic traumatic or surgical scars that existed for more than 1 year were enrolled. All atrophic scars were divided at the midline into two halves and randomly assigned to a treatment or control side. The treatment group was treated with a 1064-nm picosecond laser with an MLA handpiece (spot size: 6-8 mm, fluence: 1.0-1.2 J/cm 2 , repetition rate: 5 Hz, three passes) for 3 monthly sessions. The scar volumes were objectively measured using a three-dimensional (3D) photograph at baseline, 1 month after the first and second treatments, and 3 and 6 months after the final treatment. Subjective assessments were conducted by a blinded dermatologist and patients' self-assessment to evaluate improvements at 3 months after the final treatment. Results: The treated sides exhibited a significant volume reduction, with statistically significant improvements over the control group at 1 month after the first and second treatments and at 3 months after the final treatment (p = 0.024, 0.005, and 0.019, respectively). At 3 months after the final treatment, a blinded dermatologist correctly identified the treated side in 24 of 25 patients (96%). The patients rated the improvements as excellent (>75%) and marked (50%-75%) in 36% and 48% of patients, respectively. Conclusion: At 3 months, the 1064-nm picosecond laser with a fractionated MLA can significantly reduce the posttraumatic and postsurgical atrophic scar volume in patients with Fitzpatrick skin types III-V. Insufficient data preclude inferences regarding efficacy at 6 months.

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Histology changes of in vivo human skin after treatment with fractional 1064 nm Nd:YAG picosecond laser in different energy settings

Cited by 8 publications

References 23 publications

An update on fractional picosecond laser treatment: histology and clinical applications

An update on fractional picosecond laser treatment: histology and clinical applications

Evaluation of the safety and efficacy of a fractional picosecond 1064 nm laser for post‐acne erythema in adult Chinese patients

Efficacy and safety of fractional 1064‐nm picosecond laser for atrophic traumatic and surgical scars: A randomized, single‐blinded, split‐scar‐controlled study

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