Histological Study of Gender Differences in Accumulation of Silver Nanoparticles in Kidneys of Fischer 344 Rats

Kim, Wan-Young; Kim, Jin; Park, Jung Duck; Ryu, Hyeon Yeol; Yu, Il Je

doi:10.1080/15287390903212287

Cited by 139 publications

(102 citation statements)

References 15 publications

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“…Other exposure routes have also found sex-related differences after AgNP exposure. A 28-day oral toxicity study in rats reported a 2-fold increase in AgNP in female kidneys compared to males with higher accumulation found in all kidney regions including the cortex, medulla, inner medulla and cortical glomeruli compared to males , Kim et al, 2009. A 90-day inhalation study in rats found statistically significant increases (p < 0.01-0.05) in parameters of lung inflammation in females compared to males (Sung et al, 2008).…”

Section: Interindividual Variability In Human Population (Uf1)mentioning

confidence: 98%

Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Savery

Viñas

Nagy

et al. 2017

Regulatory Toxicology and Pharmacology

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Section: Interindividual Variability In Human Population (Uf1)mentioning

confidence: 98%

Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Savery

Viñas

Nagy

et al. 2017

Regulatory Toxicology and Pharmacology

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“…It was found that exposure to more than 300 mg of 60 nm Ag NPs in Sprague Dawley rats may lead to liver damage. 40,41 Meanwhile, it has been found that Ag NPs at a low dose (,10 mg/kg) were safe for biomedical application and had no side effects, but high dosages (.20 mg/kg) were toxic. These results inspired us to investigate sex difference-related toxicity.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

Chen

Wang²,

Long³

et al. 2013

IJN

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Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used to observe the general toxicity of reproductive organs. The immune response was influenced significantly in female mice, with obvious changes in spleen and thymus index. Hematology results showed that male mice treated with 22.5 nm gold nanoparticles received more significant infection and inflammation than female mice. Meanwhile, the biochemistry results showed that 4.4 and 22.5 nm gold nanoparticles caused more significant liver damage in male mice than female mice, while 22.5, 29.3, and 36.1 nm gold nanoparticles caused more significant kidney damage in female mice than male mice. No significant toxicological response was found in the reproductive system for female or male mice. It was found that gold nanoparticles caused more serious liver toxicity and infection in male mice than female mice. These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles.

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“…Possible explanations for increased silver levels in female rat kidneys may be gender differences in the hormonal regulation or the basement structure of the kidney. 33 A full list of physiological parameters and the determined absorption, distribution, metabolism and excretion rates, along with the associated equations, are summarized in the supplementary materials. The parameterization approach of the kinetic rates for the ionic silver and nanosilver rat PBPK model can also be found in the supplementary materials.…”

mentioning

confidence: 99%

A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles

Bachler

Goetz

Konrad³

2013

IJN

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Silver is a strong antibiotic that is increasingly incorporated into consumer products as a bulk, salt, or nanosilver, thus potentially causing side-effects related to human exposure. However, the fate and behavior of (nano)silver in the human body is presently not well understood. In order to aggregate the existing experimental information, a physiologically based pharmacokinetic model (PBPK) was developed in this study for ionic silver and nanosilver. The structure of the model was established on the basis of toxicokinetic data from intravenous studies. The number of calibrated parameters was minimized in order to enhance the predictive capability of the model. We validated the model structure for both silver forms by reproducing exposure conditions (dermal, oral, and inhalation) of in vivo experiments and comparing simulated and experimentally assessed organ concentrations. Therefore, the percutaneous, intestinal, or pulmonary absorption fraction was estimated based on the blood silver concentration of the respective experimental data set. In all of the cases examined, the model could successfully predict the biodistribution of ionic silver and 15-150 nm silver nanoparticles, which were not coated with substances designed to prolong the circulatory time (eg, polyethylene glycol). Furthermore, the results of our model indicate that: (1) within the application domain of our model, the particle size and coating had a minor influence on the biodistribution; (2) in vivo, it is more likely that silver nanoparticles are directly stored as insoluble salt particles than dissolve into Ag + ; and (3) compartments of the mononuclear phagocytic system play a minor role in exposure levels that are relevant for human consumers. We also give an example of how the model can be used in exposure and risk assessments based on five different exposure scenarios, namely dietary intake, use of three separate consumer products, and occupational exposure.

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Histological Study of Gender Differences in Accumulation of Silver Nanoparticles in Kidneys of Fischer 344 Rats

Cited by 139 publications

References 15 publications

Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice

A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles

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