Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Savery, Laura C.; Viñas, René; Nagy, Amber; Pradeep, Prachi; Merrill, Stephen J.; Hood, Alan M.; Malghan, S.G.; Goering, Peter L.; Brown, Ronald P.

doi:10.1016/j.yrtph.2017.01.007

Cited by 15 publications

(7 citation statements)

References 64 publications

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“…Our assessment describing the safety of wearing silver NPs coated masks is supported by the provisional tolerable intake derived for intravenous exposure to silver NPs released from medical devices. This provisional tolerable intake is 0.14 µg/kg bw/day (Savery et al 2017 ), therefore in the same order of magnitude that the systemic exposure obtained in Table 2 .…”

Section: Case 1: Silver Nanoparticlessupporting

confidence: 55%

Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19

2021

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The world is living a pandemic situation derived from the worldwide spreading of SARS-CoV-2 virus causing COVID-19. Facemasks have proven to be one of the most effective prophylactic measures to avoid the infection that has made that wearing of facemasks has become mandatory in most of the developed countries. Silver and graphene nanoparticles have proven to have antimicrobial properties and are used as coating of these facemasks to increase the effectivity of the textile fibres. In the case of silver nanoparticles, we have estimated that in a real scenario the systemic (internal) exposure derived from wearing these silver nanoparticle facemasks would be between 7.0 × 10–5 and 2.8 × 10–4 mg/kg bw/day. In addition, we estimated conservative systemic no effect levels between 0.075 and 0.01 mg/kg bw/day. Therefore, we estimate that the chronic exposure to silver nanoparticles derived form facemasks wearing is safe. In the case of graphene, we detected important gaps in the database, especially regarding toxicokinetics, which prevents the derivation of a systemic no effect level. Nevertheless, the qualitative approach suggests that the risk of dermal repeated exposure to graphene is very low, or even negligible. We estimated that for both nanomaterials, the risk of skin sensitisation and genotoxicity is also negligible.

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Section: Case 1: Silver Nanoparticlessupporting

confidence: 55%

Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19

2021

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“…However, there is still limited knowledge about human intravenous exposure levels and the tolerability of AgNPs in a real-world bioavailability scenario. While data from animal studies allowed for the derivation of a provisional tolerable intravenous intake of AgNPs for humans at a level of 0.14 µg/kg bw/day, estimating the magnitude of realistic nanosilver intravenous exposure remains challenging, similar to the oral intake [23].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Pro-Inflammatory Effects of Silver Nanoparticles on the Colon Depend on Time and Route of Exposure

Grodzicki,

Dziendzikowska,

Gromadzka-Ostrowska

et al. 2024

IJMS

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Nanosilver is a popular nanomaterial, the potential influence of which on humans is of serious concern. Herein, we exposed male Wistar rats to two regimens: a repeated oral dose of 30 mg/kg bw silver nanoparticles (AgNPs) over 28 days and a single-dose injection of 5 mg/kg bw of AgNPs. At three different time points, we assessed antioxidant defense, oxidative stress and inflammatory parameters in the colon, as well as toxicity markers in the liver and plasma. Both experimental scenarios showed increased oxidative stress and inflammation in the colon. Oral administration seemed to be linked to increased reactive oxygen species generation and lipid peroxidation, while the effects induced by the intravenous exposure were probably mediated by silver ions released from the AgNPs. Repeated oral exposure had a more detrimental effect than the single-dose injection. In conclusion, both administration routes had a similar impact on the colon, although the underlying mechanisms are likely different.

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“…This was evidenced by nanoparticle accumulation, increased weight, and histopathological changes. The histopathological features showed inflammation and brownish colour (degradation of red blood cells/ lymphocyte reduction) in the spleen tissue (29) .…”

Section: Iron Nanoparticles (Ionps) and Supramagnetic Iron Nanopartic...mentioning

confidence: 99%

“…A study by Savery et al (29) found the toxicity induced by silver nanoparticles (AgNPs). The immunotoxic effects of AgNPs appear as a decrease in the number of lymphocytes and decreased natural killer (NK) cell activity.…”

Section: Iron Nanoparticles (Ionps) and Supramagnetic Iron Nanopartic...mentioning

confidence: 99%

Toxicity of Nanoparticles on The Spleen in Animal Studies: A Scoping Review

Sutomo

Ahsani

Fidianingsih

2022

jifi

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Nanotechnology has been developing in the medical field, but some nanoparticles have toxic effects on the body, including the spleen. This scoping review represents an attempt to take stock of existing research results related to the presence or absence of toxicity to the spleen caused by nanoparticles involving experimental animals. A scoping review was conducted to synthesize and map the toxicity of nanoparticles. It has been searched on PubMed databases for spleen or lien and toxic or toxicity, and nanoparticles or dendrimers or "metal nanoparticles" or “magnetite nanoparticles” or nanoshells or “multifunctional nanoparticles” or nanocapsules or nanoconjugates or nanodiamonds or nanogels or nanospheres. Seventeen studies met our inclusion criteria. In conclusion, it showed that 13 nanoparticles could cause toxicity in rodent spleen and as many as 4 nanoparticles did not cause toxicity in rodent spleen.

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Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Cited by 15 publications

References 64 publications

Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19

Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19

In Vivo Pro-Inflammatory Effects of Silver Nanoparticles on the Colon Depend on Time and Route of Exposure

Toxicity of Nanoparticles on The Spleen in Animal Studies: A Scoping Review

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