Histological observations of pulpal replacement tissue in immature dog teeth after revascularization of infected pulps

Abstract

Within the limitation of this study, it can be concluded that residual pulp tissue can remain in the canals after revascularization procedures of immature teeth with artificially induced pulp infection. This can lead to the misinterpretation that true pulpal regeneration has occurred. Ingrowth of apical bone into the root canals undergoing revascularization can interfere with normal tooth eruption if ankylosis occurs.

Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: A systematic review

“…A total of 54 animals were treated: 44 dogs, [10][11][12][13][14][15][16][17][18]21,22 six ferrets, 19 and four sheep. 20 Tooth types, numbers, and treatment protocols T A B L E 2 (Continued) applied to the teeth are summarized in Table 2 In six studies, 14,18-22 each tooth was considered to be an independent unit.…”

“…15,18,22 All the included animal studies shared a common feature, which was a lack of formation of pulp with an odontoblast-like cell layer and dentin-like structure with all scaffold types. The new tissues resembled cementum, PDL, and bone in the majority of the cases, either with the use of BC scaffold or with other types of scaffolds, and even in those which did not apply any scaffold.…”

“…1 Formation of intracanal hard tissue was reported in 80% of the studies which used BC scaffold, and 100% of the studies which used alternative scaffolds. Because of the lack of information in the published studies regarding the number of the teeth which showed intracanal hard tissue, it was difficult to determine precisely whether 18 [n=9T] Thibodeau et al 22 [n=NR] Tawfik et al 12 [n=NR] Yoo et al 15 [n=NR] Torabinejad et al 19 [n=2T]…”

“…Forty-six percent of the reviewed studies reported formation of PDL-like tissues. Two studies showed pulp tissue in a few cases, 18,22 and one study reported formation of pulp-like tissue after regeneration without showing odontoblast cells. 16 One study reported formation of pulp-like tissue with odontoblast-like cells in the teeth treated with BC+ scaffolds.…”

Calcium silicate-based cements and functional impacts of various constituents

“…MTA has some drawbacks such as long setting time 10) , poor handling characteristics 11) , and costs 12) . The promising results obtained from MTA research have encouraged further investigation of materials with similar favorable properties that are less expensive, as well as have fewer drawbacks when compared with the original MTA.…”