Histological, Histochemical and Immunohistochemical Study on the Structure of Meibomian Gland of Adult Male Albino Rat

The morphogenesis of the rabbit meibomian gland in relation to sex hormones: Immunohistochemical and transmission electron microscopy studies

“…In this study, the epithelial cells of the connecting ductules contain keratohyalin granules, and the central duct is lined by a keratinizing layer of keratohyalin granules. In contrast, [ 24 ], rats stated that the central duct is lined by stratified squamous epithelium and appears keratinized in some areas of the duct [ 25 ] stated that the terminal part of the central duct is lined by squamous epithelium with modified keratinization. It is thought that an increase in the amount of keratinization compared lipid production helps in separating the eyelids [ 26 ].…”

“…The same results were published by other researchers who reported that the MG is considered the androgen target organ and plays a role in regulating lipid and gene expression production in the gland [ 38 ]. They added that any deficiency in the androgen leads to dysfunction of the MG, especially in women who are associated with changes in the MG, an increase in the symptoms and signs of dry eye, and altered lipid patterns in the secretion of the MG [ 24 , 39 , 40 ]. Another clinical finding is demonstrated as painful eye, high sensitivity to light, blurred vision, orifice metaplasia, and a decrease in the tear film break uptime.…”