Histological grading and clinical stage at presentation in breast carcinoma

Sø, Thoresen

doi:10.1038/bjc.1982.226

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…Both methods have a high level of reproducibility (11,5). Grading is a readily available parameter (12) and is strongly related to both prognosis (13) and staging (14). Further, a consistent relationship has been demonstrated between histological grade and ER receptor values (2,3,4).…”

Section: Discussionmentioning

confidence: 93%

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

Sø

Thorsen

Tangen³

et al. 1982

Breast Cancer Res Tr

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Histological grading of 160 primary infiltrating breast carcinomas showed that both oestrogen and progesterone receptor status are strongly related to grade, tumours that are receptor positive tending to be of lower grade than the receptor negative. The nuclear factors used in grading were those that determined this association. In addition the absence/presence of both receptors was reflected in the grade present, beyond the correlation expected on the basis of either receptor alone.

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Section: Discussionmentioning

confidence: 93%

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

Sø

Thorsen

Tangen³

et al. 1982

Breast Cancer Res Tr

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“…According to the Bloom Richardson classification for classifying the tumors, the tumors were classified into 6 stages and 3 grades. 20 – 22 To evaluate the possible relationships between steroid hormone receptors mRNA level and clinical characteristics of the tumor; ie, clinical staging and histopathological grading, analysis was performed using chi square test ( Tables 6 and 7 ). For this purpose, all steroid receptors according to their mRNA content were divided in two subgroups as low and high mRNA level.…”

Section: Resultsmentioning

confidence: 99%

The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients

Esfahlan¹,

Zarghami

Jahanban-Esfahlan

et al. 2011

Breast Cancer�(Auckl)

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BackgroundObesity has been associated with increased mortality from hormone dependant cancers such as breast cancer which is the most prevalent cancer in women. The link between obesity and breast cancer can be attributed to excess estrogen produced through aromatization in adipose tissue. The role of steroid hormone receptors in breast cancer development is well studied but how obesity can affect the expression pattern of steroid hormones in patients with different grades of breast cancer was the aim of this study.MethodsIn this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI < 25 kg/m2 and 34 obese, BMI ≥ 25 kg/m2). The mean age of participants was 44.53 ± 1.79 yr (21–70 yr). The serum level of estrogen, progesterone and androgen determined by ELISA. Following quantitative expression of steroid hormone receptors mRNA in tumor tissues evaluated by Real-time PCR. Patients with previous history of radiotherapy or chemotherapy were excluded. SPSS 16 was used for data analysis and P < 0.05 considered statistically significant.ResultsThe difference in ERα, ERβ and PR mRNA level between normal and obese patients was significant (P < 0.001). In addition, the expression of AR mRNA was found to be higher than other steroid receptors. There was no significant relation between ERβ gene expression in two groups (P = 0.68). We observed a significant relationship between ERα and AR mRNA with tumor stage and tumor grade, respectively (P = 0.023, P = 0.015).ConclusionAccording to the obtained results, it is speculated that obesity could paly a significant role in estrogen receptors gene expression and also could affect progression and proliferation of breast cancer cells.

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“…Well‐differentiated (grade 1) IDC have a have a low Bloom–Richardson score (3–5), while intermediate grade (grade 2) tumors have a score from six to seven and poorly differentiated (grade 3) tumors have a score from eight to nine. The prognostic importance of histologic grade has been repeatedly tested and shown to directly correlate with the frequency of lymph node metastasis, the frequency of disease recurrence and death caused by invasive carcinoma, all independent of clinical stage (8–15).…”

Section: Infiltrating Ductal Carcinomamentioning

confidence: 99%

Molecular and Morphologic Distinctions between Infiltrating Ductal and Lobular Carcinoma of the Breast

2007

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Histopathologic distinction between ductal and lobular carcinomas of the breast has been made since 1941. Together, these two subtypes account for >95% of all mammary carcinomas. With the recent advances in molecular techniques, our understanding of the biology behind these carcinomas has greatly expanded. The genomic aberrations in mammary carcinoma are highly complex and appear to be more associated with tumor grade rather than any histopathologic subtype. Protein and RNA expression profiling reveals a classification of mammary carcinoma that has some overlap with traditional histopathology and can at least partially explain clinical behavior. The goal of this review is to present what is currently known about the molecular profiles of infiltrating ductal and lobular carcinoma and how they relate to conventional histopathology and biologic behavior.

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Histological grading and clinical stage at presentation in breast carcinoma

Cited by 9 publications

References 6 publications

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients

Molecular and Morphologic Distinctions between Infiltrating Ductal and Lobular Carcinoma of the Breast

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