Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

Sø, Thoresen; Thorsen, T.; Tangen, M; Hartveit, F

doi:10.1007/bf01806938

Cited by 14 publications

(9 citation statements)

References 19 publications

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“…The lower grade tumors showed a high ER and PR positivity, being similar to other studies (8,23). The overexpression/amplification of Her2/neu in different histological grades of invasive ductal carcinoma of breast has been subject of interest.…”

Section: Discussionsupporting

confidence: 85%

Correlation of hormone receptors with her-2 neu protein expression and the histological grade in invasive breast cancers in a cohort of saudi arabia

Arafah¹

2012

TJPATH

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Objective: Data on Hormone Receptor and Her-2/neu expression in breast cancers from Saudi Arabia and Gulf Region is sparse. We undertook this study to describe the patterns of hormone receptor and Her-2/neu protein expression in breast carcinoma and compared them with the histological grade at a University Hospital in Riyadh. Material and Method:We conducted a retrospective study on 164 invasive ductal carcinoma of breast between the year 2002 and 2008. Immunohistochemical analysis for Estrogen and Progesterone Receptor and Her-2/neu was done in all the cases. Fluorescent in situ hybridization for Her-2/neu gene amplification was performed in all 2+ cases and few equivocal 1+ and 3+cases by immunohistochemistry. Correlation between Estrogen and Progesterone Receptor and Her-2/ neu amplification and grade of tumor was calculated. Results:The expression of Estrogen Receptor, Progesterone Receptor were significantly correlated (p<0.001). Also, there was a significant negative correlation between expression of hormone receptor and Her-2/neu amplification. The histologic grade of the tumor was significantly correlated to the expression of both Estrogen and Progesterone Receptor. However, the relationship between Her-2/ neu amplification and grade was not significant and many of the grade III tumor were Her-2/neu negative. In addition, Her-2/neu gene amplification by fluorescent in situ hybridization was observed in 84.6% of breast cancer that were 3+ and in 18.75 % cases that were 2+ by immunohistochemistry. Conclusion: Prevalence of Estrogen and ProgesteroneReceptor expression and Her-2/neu amplification in breast cancer in the Saudi Arabian population is similar to that reported internationally. There is a negative correlation between hormone receptors expression and Her-2/neu amplification. However not all of the high-grade breast cancers showed Her-2/neu positive status. Bulgular: Östrojen ve progesteron reseptörü ekspresyonu ilişkili saptanmıştır (p<0.001). Hormon reseptörleri ekspresyonu ile Her-2/neu arasında negatif ilişki gözlenmiştir. Histolojik derece östrojen ve progesteron reseptörü ekspresyonu ile anlamlı ilişki göstermektedir. Ancak, Her-2/neu amplifikasyonu ile derece arasında ilişki saptanmamıştır ve çoğu derece III tümörler Her-2/neu olumsuz bulunmuştur. Floresan in situ hibridizasyon ile meme kanserlerinin %84.6'sı 3+, %18.75'i 2+ bulunmuştur.Sonuç: Suudi Arabistan' da östrojen ve progesteron reseptörü ekspresyonu ve Her-2/neu amplifikasyonu oranları literatür ile benzerlik göstermektedir. Hormon reseptörü ekspresyonu ile Her-2/ neu amplifikasyonu ters ilişkilidir. Ancak, tüm yüksek dereceli meme kanserleri Her-2/neu ile pozitiflik göstermemektedir.

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Section: Discussionsupporting

confidence: 85%

Correlation of hormone receptors with her-2 neu protein expression and the histological grade in invasive breast cancers in a cohort of saudi arabia

Arafah¹

2012

TJPATH

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“…The grade of tumor in our study was significantly inversely correlated with the expression of PR (P value 0.0006) whereas in previous studies, both ER and PR expression were significantly inversely correlated [9]. The lower grade tumors showed high ER and PR positivity as evident from the other studies [15,27]. The relationship between grade of tumor and Her2/neu expression was found to be not significant and vast majority of Her2/neu negative tumors were grade III.…”

Section: Discussioncontrasting

confidence: 68%

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

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The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma.

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“…For the joint ER/PR subgroup, the likelihood of a positive HER-2/neu status decreased significantly from ER 30 The inverse association between steroid hormone receptors and HER-2/neu has also been described in clinical studies. 8 9 11 12 Most studies on this inverse 26 Tumour grade is one of the best predictors for HER-2/neu overexpression, and may therefore interfere with PR as an independent predictor for HER-2/neu. However, our findings showed that this is not the case.…”

Section: Discussionmentioning

confidence: 99%

“…11 12 However, ER + breast cancers that are PR 2 are more likely to be of a high grade, resistant to tamoxifen, and more aggressive, independent of treatment. [26][27][28] Therefore, it is not clear whether tumour grade and PR remain independent predictors for HER-2/neu in a multivariate model. We examined in a multivariate analysis the relation between HER-2/neu overexpression and other clinicopathological factors in women with operable breast cancer.…”

mentioning

confidence: 99%

Association between tumour characteristics and HER-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer

Neven²,

et al. 2005

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Aims:To investigate the association between tumour characteristics and HER-2/neu by immunohistochemistry in primary operable breast cancer.Methods:The association between HER-2/neu and other clinicopathological factors was evaluated in 1362 consecutive patients with primary breast cancer treated between 2000 and July 2003 in one centre. Microscopic tumour size, tumour grade, lymph node status, patient’s age, oestrogen receptor (ER), progesterone receptor (PR), and joint ER/PR status were evaluated, using the χ2test for univariate analysis and logistic regression for multivariate analysis. The hormone receptors and HER-2/neu were studied immunohistochemically. Using the HER-2/neu DAKO scoring system, scores of 0, 1+, or 2+ were defined as negative and 3+ as positive. Data for DAKO scores 2+/3+ versus 0/1+ are also presented.Results:Hormone receptor negative breast cancers were more often HER-2/neu positive than hormone receptor positive cancers, both for ER (28.7%v6.8%) and PR (19.9%v5.9%). In multivariate analysis, both ER, PR, and tumour grade were independently associated with HER-2/neu. In ER+tumours, HER-2/neu overexpression was significantly lower in PR+than in PR−cases (11.5%v5.4%). HER-2/neu overexpression (2.7%) was lowest in the large subgroup of ER+PR+tumours with low tumour grade (grade 1–2), comprising 46.1% of all patients.Conclusions:ER, PR, and tumour grade are independent predictors for HER-2/neu overexpression in women with primary operable breast cancer. ER and PR are negatively associated with HER-2/neu, whereas tumour grade is positively associated with HER-2/neu. In women with ER+tumours, PR status also affects the likelihood of HER-2/neu expression.

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Oestrogen and progesterone receptor content and the distribution of histological grade in breast cancer

Cited by 14 publications

References 19 publications

Correlation of hormone receptors with her-2 neu protein expression and the histological grade in invasive breast cancers in a cohort of saudi arabia

Correlation of hormone receptors with her-2 neu protein expression and the histological grade in invasive breast cancers in a cohort of saudi arabia

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Association between tumour characteristics and HER-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer

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