Histological Findings After Colocystoplasty And Gastrocystoplasty

Abstract

Periodic prospective biopsy evaluation of children who have undergone either colocystoplasty or gastrocystoplasty failed to reveal any histological evidence of malignancy after 10-year followup. However, histological evidence of a premalignant lesion 13 years after followup suggests that screening for premalignant lesions should be initiated no later than 6 to 10 years following enterocystoplasty.

Histologic findings after gastrocystoplasty in rabbits

“…Neither the present animal study nor our earlier studies in human material were able to demonstrate changes for malignancy or premalignant alterations after gastrocystoplasty [18]. Close et al [10] found transitional cell hyperplasia and metaplasia but no malignancy or DNA abnormalities in rats using flow cytometry after gastrocystoplasty at 21 to 27 months of follow-up.…”

Quality of life: urinary bladder augmentation or substitution in children

“…These vary depending on the type of gastro-intestinal segment used [1][2][3]. Due to the risks of metabolic disturbances and other potential complications, patients need long and continuous followup and care [4][5][6][7][8][9].…”

Increased cancer risk of augmentation cystoplasty: Possible role for hyperosmolal microenvironment on DNA damage recognition

“…Approximately forty percent of these malignancies were reported to be transitional cell carcinomas, suggesting metaplasia in the enteric patch [3]. Experimental animal data [4–6] and surveillance biopsy data in humans [7] demonstrate that transitional metaplasia is frequently observed in the gastrointestinal segment of bladder augmentations, and this metaplasia may herald the onset of more severe dysplasia and malignancy. Recent analyses of biopsied enterovesicular anastomoses revealed mutations in p53 by restriction site mutation assay in 20% of patients, but found no mutations in the native bladder tissue [8], suggesting a tissue-specific response to the bladder microenvironment.…”