Histological Features of Periprosthetic Mammary Capsules: Silicone vs. Polyurethane

Bassetto, Franco; Scarpa, Carlotta; E, Caccialanza; Montesco, Maria Cristina; Magnani, Patrizia

doi:10.1007/s00266-010-9483-0

Cited by 38 publications

(25 citation statements)

References 13 publications

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“…Partially agreeing with Bassetto et al 17 , who obtained the presence of synovial metaplasia in the polyurethane and textured groups, which was bigger in the polyurethane group, in this study was found this variable, however, there was no difference between the groups. The same authors concluded that synovial metaplasia is the most important protective factor against capsular contracture.…”

Section: Evaluation Of Synovial Metaplasiasupporting

confidence: 50%

“…In according to Bassetto et al 17 , the foreign body reaction was bigger in the polyurethane group. In the textured group, this reaction was present in all members in a milder way, differing from the present study in which the foreign body reaction was absent in the textured group, although this study has been carried out in rats and the other in humans.…”

Section: Evaluation Of Foreign Body Reactionmentioning

confidence: 99%

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Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

Silva¹,

Ribas-Filho²,

Czeczko³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS:Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 days. Were analyzed the following parameters: foreign body reaction, granulation tissue, presence of myofibroblasts, neoangiogenesis, presence of synovial metaplasia, capsular thickness, total area and collagen percentage of type I and III, in capsules formed around silicone implants in both groups. RESULTS:The foreign body reaction was only present in the four polyurethane subgroups. The formation of granulation tissue and the presence of myofibroblasts were higher in the four polyurethane subgroups. Regarding to neoangiogenesis and synovial metaplasia, there was no statistical difference between the groups. Polyurethane group presented (all subgroups) a greater capsule thickness, a smaller total area and collagen percentage of type I and a higher percentage area of type III, with statistical difference. CONCLUSION:The use of polyurethane-coated implants should be stimulated by the long-term results in a more stable capsule and a lower incidence of capsular contracture, despite developing a more intense and delayed inflammatory reaction in relation to implants with textured surface.

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Section: Evaluation Of Synovial Metaplasiasupporting

confidence: 50%

Section: Evaluation Of Foreign Body Reactionmentioning

confidence: 99%

Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

Silva¹,

Ribas-Filho²,

Czeczko³

et al. 2016

Acta Cir. Bras.

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“…In contrast, PU was associated with a much greater inflammatory response, with a persisting insulation of the patches and, occasionally, granulomas, which have also been reported in other applications. 37,38 Whether a physicochemically different PU might more favorably affect host tissue responses will be the subject of future investigations.…”

Section: Figmentioning

confidence: 99%

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

Pontailler

Illangakoon

Williams

et al. 2015

Tissue Engineering Part A

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As part of a program targeted at developing a resorbable valved tube for replacement of the right ventricular outflow tract, we compared three biopolymers (polyurethane [PU], polyhydroxyalkanoate (the poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-4-hydroxyvalerate) [PHBVV]), and polydioxanone [PDO]) and two biofunctionalization techniques (using adipose-derived stem cells [ADSCs] or the arginine-glycine-aspartate [RGD] peptide) in a rat model of partial inferior vena cava (IVC) replacement. Fifty-three Wistar rats first underwent partial replacement of the IVC with an acellular electrospun PDO, PU, or PHBVV patch, and 31 nude rats subsequently underwent the same procedure using a PDO patch biofunctionalized either by ADSC or RGD. Results were assessed both in vitro (proliferation and survival of ADSC seeded onto the different materials) and in vivo by magnetic resonance imaging ( MRI), histology, immunohistochemistry [against markers of vascular cells (von Willebrand factor [vWF], smooth muscle actin [SMA]), and macrophages ([ED1 and ED2] immunostaining)], and enzyme-linked immunosorbent assay (ELISA; for the expression of various cytokines and inducible NO synthase). PDO showed the best in vitro properties. Six weeks after implantation, MRI did not detect significant luminal changes in any group. All biopolymers were evenly lined by vWF-positive cells, but only PDO and PHBVV showed a continuous layer of SMA-positive cells at 3 months. PU patches resulted in a marked granulomatous inflammatory reaction. The ADSC and RGD biofunctionalization yielded similar outcomes. These data confirm the good biocompatibility of PDO and support the concept that appropriately peptide-functionalized polymers may be successfully substituted for cell-loaded materials.

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“…Furthermore, this PSE is not consistently reported although there appears to be a higher prevalence with textured implants [20, 21]. While not used as frequently as textured or smooth implants, polyurethane foam-coated implants have been reported to generate a similar layer [22]. More recently, the inner layer has been identified as a metaplasia like synovial layer [3, 9, 24] consisting of macrophages and fibroblasts [23], and at this point, both names are used to describe the same layer [21].…”

Section: Introductionmentioning

confidence: 99%

The Histological Composition of Capsular Contracture Focussed on the Inner Layer of the Capsule: An Intra-Donor Baker-I Versus Baker-IV Comparison

et al. 2018

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Histological Features of Periprosthetic Mammary Capsules: Silicone vs. Polyurethane

Cited by 38 publications

References 13 publications

Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

Histological evaluation of capsules formed by silicon implants coated with polyurethane foam and with a textured surface in rats

Polymer-Based Reconstruction of the Inferior Vena Cava in Rat: Stem Cells or RGD Peptide?

The Histological Composition of Capsular Contracture Focussed on the Inner Layer of the Capsule: An Intra-Donor Baker-I Versus Baker-IV Comparison

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