Histological, electron‐microscope and enzyme studies of submucous fibrosis of the palate

Sirsat, Satyavati M.; Khanolkar, V. R.

doi:10.1002/path.1700790107

Cited by 18 publications

(7 citation statements)

References 15 publications

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“…The connective tissue changes are characterized by the deposition of dense collagen fiber bundles in the oral mueosa, which develop a hyalinized appearance in moderate and advanced stages of the disease (3). Collagen fiber bundles were found to be abnormal, revealing hyaline degeneration, fragmentation or elastotic degeneration (3,(5)(6)(7). Varying and altered staining characteristics have also been described (3,8).…”

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confidence: 99%

Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF)

Reichart¹,

Wyk

Becker³

et al. 1994

J Oral Pathology Medicine

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The distribution of procollagen type III, collagen type VI and tenascin was studied in biopsy specimens from the buccal mucosa of 19 Indian women with confirmed oral submucous fibrosis (OSF) using the immunogold-silver staining technique. Immunohistochemistry revealed a loss of stainable procollagen type III and collagen type VI in the fibrotic zones of oral submucous fibrosis compared to normal oral mucosa. Tenascin was noted only very faintly at the subepithelial basement membrane. The present study showed that procollagen type III and collagen type VI in OSF were expressed in a specific pattern which allows a clear differentiation between fibrotic areas and adjacent apparently normal connective tissue stroma. Loss of procollagen type III, and therefore a probable predominance of collagen type I in collagen fiber bundles, and an almost complete loss of collagen type VI might explain the stiffness of the oral mucosa in patients with OSF. The immunohistochemical findings provided evidence that the process of fibrosis starts in the deeper subepithelial connective tissue stroma and not close to the subepithelial basement membrane. Further studies are required to determine whether OSF is due to increased or altered synthesis and deposition of extracellular matrix proteins, altered fibrolysis or both.

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mentioning

confidence: 99%

Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF)

Reichart¹,

Wyk

Becker³

et al. 1994

J Oral Pathology Medicine

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“…Another patient under my care, a child of 12, has the typical changes in her palate and to a lesser extent in her cheeks and yet she has had chillies on no more than two occasions -each intake accompanied by blistering of oral mucosa. Sirsat & Khanolkar (1960) were able to produce an extreme connective tissue response in rat palates by painting on capsaicin, but only if the rats showed either vitamin B or protein depletion. Normal rats showed only a limited mucosal and connective tissue change.…”

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confidence: 99%

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O'Riordan

1974

Proceedings of the Royal Society of Medicine

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“…1,2 The etiopathogenesis of OSMF is yet not established but the factors incriminated are: race and religion, genetic, malnutrition and poor dental hygiene, excessive spicy foods, habits of chewing betel nuts, betel leaves and tobacco. [3][4][5][6][7] Some considers it collagen disorder and precancerous lesion due to its frequent association with cancer of oral cavity. [8][9][10][11] The reported histopathological changes are fibroelastotic transformation of the connective tissues in the lamina propria, round cell infiltration with less vascularity, associated with epithelial atrophy, acanthotic and paracanthotic changes.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of local and systemic corticosteroid and hyaluronidase therapy in oral submucous fibrosis: a histopathological study

Bansal

2019

Int J Otorhinolaryngol Head Neck Surg

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Background: As the etiopathogenesis of OSMF is not well established, a myriad of different medical and surgical modalities of treatment are reported however studies on histopatholgical changes after treatment are very sparse. There are reports on various regimens of steroids using different molecules, doses and routes of administration and their combination with other drugs. These were the driving factors to conduct this study. This histopathological study was conducted to know the efficacy of various forms of steroid therapy in various combinations.Methods: This prospective randomized single blinded outcome based study was conducted in the department of Otorhinolaryngology (ENT) and Pathology in a tertiary care medical college hospital. The 150 clinically diagnosed patients were divided into 5 groups: A, B, C, D and E. Each group was treated differently with different modes of administration of steroids with and without combinations of other medicines. To study histopathological changes before and after treatment, biopsy was taken in 100 patients who gave their consent for the same. Results: The various histopathological changes observed in the tissues taken after the treatment in 100 patients, were in terms of changes in the epithelium towards normalisation, decrease in fibrous tissue in the submucosa, decrease in the cellular infiltration, appearance of new capillaries, restoration of glandular activity and decrease in the fibrosis of muscles. The calculated Chi square value (p>0.05) was found less than table value.Conclusions: Local and systemic corticosteroid and hyaluronidase therapy in patients with OSMF were found effective. However, histopathologically, it was not found statistically significant whether corticosteroids are given locally and/or systemic with or without injection hyaluronidase.

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Histological, electron‐microscope and enzyme studies of submucous fibrosis of the palate

Cited by 18 publications

References 15 publications

Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF)

Distribution of procollagen type III, collagen type VI and tenascin in oral submucous fibrosis (OSF)

Cases

Efficacy of local and systemic corticosteroid and hyaluronidase therapy in oral submucous fibrosis: a histopathological study

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