Histological Differentiation between Phaeochromocytoma and Melanoma of the Suprarenal Gland

Dick, John C.; Ritchie, Grace M.; Thompson, Henry J.

doi:10.1136/jcp.8.2.89

Cited by 27 publications

(8 citation statements)

References 8 publications

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“…Primary adrenal melanoma is a highly aggressive tumor that affects middle-aged adults and manifests itself as a painful flank mass, although distant lymph node metastasis can be seen on the initial examination. 6 The size of the lesions ranges from 8 to 17 cm in maximal diameter [1][2][3][4][5][6] and the tumors are com- posed of soft gray-brown to brown-black tissue with areas of hemorrhage and necrosis. 5,7 A histologic study reveals polygonal or spindle cells displaying an oval-toround nucleus with a prominent nucleolus and containing brown intracytoplasmic pigment.…”

Section: Discussionmentioning

confidence: 99%

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Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case

2004

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The adrenal gland can frequently be the site of metastatic deposits, including malignant melanocytic tumors; however, primary melanoma of the adrenal gland is exceptional. We reviewed 18 cases reported in the English literature to date, and here add another case which occurred in a 78-year-old man. The patient underwent right suprarenalectomy and the pathology report showed a malignant melanoma of the adrenal gland. Immunohistochemical staining revealed a positive antibody-specific cytoplasmic reactivity to S-100 and HMB-45 proteins with a negative reaction for cytokeratin (AE1, AE3), synaptophysin, chromogranin and neuron-specific enolase. There are diagnostic criteria for accepting an adrenal melanoma as primary; however, an autopsy is the final step to confirm this infrequent pathology.

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Section: Discussionmentioning

confidence: 99%

“…Primary malignant melanoma of the adrenal gland is extremely rare, with only 18 cases [1][2][3][4][5][6] reported in the English literature. It is always difficult to differentiate a primary melanoma from either a metastatic melanoma of the adrenal gland or from a pigmented pheochromocytoma.…”

Section: Introductionmentioning

confidence: 99%

Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case

2004

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“…A hemithyroidectomy had been performed nine years previously, but no histological report was quoted. Dick, Ritchie, and Thompson (1955) described a phaeochromocytoma which was successfully removed surgically. Eighteen months later the patient developed a mass in the left side of his neck which was subsequently confirmed as being carcinoma-developing in a simple adenoma of the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Phaeochromocytoma Associated with Carcinoma of the Thyroid

Sahay¹

1962

BMJ

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“…In 1955, Dick et al [2] published a new case of melanoma of the adrenal gland that occurred together with a pheochromocytoma, establishing the histological differentiation between the two. Twelve years later Sasidharan et al [3] published an article describing a primary melanoma of the adrenal gland in a 62-year-old woman that was discovered during a routine medical examination.…”

Section: Introductionmentioning

confidence: 99%

Primary melanoma of the adrenal gland: a case report and review of the literature

et al. 2011

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BackgroundPrimary melanoma of the adrenal gland is exceptionally rare as demonstrated by the few cases reported in the medical literature, and it has a high fatality rate. We present the case of a patient with two relapses and survival to date.Case reportWe describe the case of a 58-year-old Caucasian woman who consulted her doctor with symptoms of asthenia, anorexia and weight loss. A mass was palpated in her abdomen at the height of the left hypochondrium. A computed tomographic scan revealed a retroperitoneal mass measuring 10 cm × 15 cm originating in the left adrenal gland. A left nephroadrenalectomy and splenectomy were performed. Histopathologically, the retroperitoneal mass corresponded to a melanoma, and no primary melanoma was found in any other location. The patient was treated with interferon-α-2b. Three years after her diagnosis the patient presented with a retroperitoneal relapse of the mass measuring 7.2 cm, which was removed. Five years after the first relapse a new retroperitoneal relapse mass was diagnosed, which was also removed. Since then the patient has been healthy and free from illness.ConclusionHistological and immunohistochemical studies, together with the criteria described by Ainsworth et al. and Carstens et al., allowed us to diagnose primary melanoma of the adrenal gland.

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Histological Differentiation between Phaeochromocytoma and Melanoma of the Suprarenal Gland

Cited by 27 publications

References 8 publications

Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case

Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case

Bilateral Phaeochromocytoma Associated with Carcinoma of the Thyroid

Primary melanoma of the adrenal gland: a case report and review of the literature

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