Bilateral Phaeochromocytoma Associated with Carcinoma of the Thyroid

Sahay, U.

doi:10.1136/bmj.1.5289.1391

Cited by 15 publications

(2 citation statements)

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“…So far as we know, there have been seven reported cases of adenocarcinoma of the thyroid gland associated with bilateral pheochromocytoma in the world, and after 1959, in which the existence of medullary carcinoma of the thyroid gland had been emphasized by Hazard et al, three such cases were reported (Sipple, 1961;Sahay, 1962;Ruppert et al, 1966).…”

Section: Discussionmentioning

confidence: 99%

“…In Sipple's original paper (1961), adenocarcinoma of the thyroid gland was postulated to associate with pheochromocytoma, though it is now generally accepted that this syndrome includes pheochromocytoma, medullary carcinoma of the thyroid gland and parathyroid adenoma. Subsequent to the publication of this report, some cases of pheochromocytoma accompanied with adenocarcinoma of the thyroid gland had been documented (Sahay, 1962;O'Brien, 1963;Kaye and Zak, 1964), until Williams (1965) pointed out that the association between pheochromocytoma and carcinoma of the thyroid gland was specifically with medullary carcinoma of the thyroid gland.…”

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Bilateral pheochromocytoma associated with papillary adenocarcinoma of the thyroid gland. Report of an unusual case.

et al. 1985

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A 31-year old woman was admitted to our clinic complaining of high blood pressure, dizziness, constipation, mental irritability and weight loss. The physical examination revealed goiter in her neck. The plasma levels of norepinephrine and epinephrine were 3.45 and 0.76 ng/ml, respectively. Urinary excretion of norepinephrine was 1 mg and epinephrine was 32.2 micrograms/24-hours. The examination by radiography and radioactive isotope revealed a tumor in the left adrenal region and another in the left lower lobe of the thyroid. After the operations, pheochromocytoma and papillary adenocarcinoma of the thyroid gland were recognized pathologically. However, 17 months later, the recurrence of pheochromocytoma in the contralateral adrenal region was discovered and removed. Although the co-existence of bilateral pheochromocytoma and papillary adenocarcinoma of the thyroid gland is not one of multiple endocrine neoplasia, to the best of our knowledge, only 7 such cases have been reported in the published literature.

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Bilateral pheochromocytoma associated with papillary adenocarcinoma of the thyroid gland. Report of an unusual case.

et al. 1985

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Solid carcinoma of the thyroid gland.Analysis of 53 cases

Ibañez

Cole

Russell

et al. 1967

Cancer

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Of a series of thyroid carcinomas, approximately 10% have been of the solid type. The histologic pattern of solid thyroid carcinoma is distinctive: I t is the only type that contains amyloid and it is unmixed with other types. The incidence in males and females is essentially equal. Solid carcinoma tends to metastasize to the cervical lymph nodes and the mediastinum. T h e diseases with which it is associated brings this type into special perspective among thyroid cancers. Its histologic pattern is not a guide to the prognosis. The treatment of choice is total thyroidectomy with resection of all regional metastases. Of 33 patients who were followed for five years or more after operation, 40% had no evidence of thyroid cancer a t the time of this study; 15% were living with disease; 36% had died of the disease and 9% had died of other causes. Institute. To the present time the study includes 562 microscopically proven carcinomas. Of these, 53 (9.4%) were of the solid variety.This type was chosen for the present discussion because it differs from all the other types in several respects:1. Solid carcinoma is not mixed with other types and its cellular morphology is distinctive; 2. T h e solid type is the only thyroid carcinoma that contains amyloid;3. From our experience, these tumors tend to spread through the lymphatics to the cervical lymph nodes and the mediastinum; 4. In contrast to the sex incidence of other types of thyroid carcinoma, which is two or more times higher in females, the incidence of solid carcinoma is essentially the same in males and females.In addition, the reports i n the medical literature of the association of solid carcinoma with pheochromocytoma, parathyroid adenoma, and Marfan's, Cushing's and the carcinoid syndromes brings this type into special perspective among cancers of the thyroid gland. A clinicopathologic analysis of these 53 cases, particularly with respect to these points, is presented. MATERIALS AND METHODST h e hospital charts of the 53 patients bearing this type of thyroid cancer were reviewed. T h e thyroid glands of 41 patients were examined by the routine paraffin section technique and those of 12 patients by the whole organ subserial section technique. Sections of all primary and metastatic lesions were stained with hematoxylin and eosin for microscopic examination and special stains were employed for study of the amyloid. Crystal violet, Congo red, PAS with and without diastase digestion, alcian blue, mucicarmine and silver stains were employed routinely. ANALYSIS OF CASESAge, sex and mcc: T h e ages of these 53 patients ranged from 15 to 82 years, the numbers of patients in the fourth, fifth, sixth and seventh decades of life being almost equal. Their median age at the onset of symptoms was 48 years and upon admission to this hos-706

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Pheochromocytoma and medullary carcinoma of thyroid

Huang

McLeish

1968

Cancer

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Three members of a kindred exhibiting pheochromocytoma and amyloid‐producing medullary carcinoma of thyroid are presented to support the belief that this syndrome is a distinct clinical entity and is probably genetically determined. Ultrastructural studies of the pheochromocytoma and the medullary carcinoma were carried out in one case. In the pheochromocytoma typical secretory granules identical to those described in the normal and neoplastic adrenal medullary cells were found. In medullary carcinoma of the thyroid distinct and characteristic secretory granules were shown for the first time by electron microscopy and a close relationship between the secretory granules and the local amyloid deposits was observed. A possible mechanism for local amyloid formation in this tumor was discussed. Morphology of the secretory granules of medullary carcinoma of the thyroid was different from that of pheochromocytoma but resembled that described in the parafollicular cells of the thyroid in rats. The finding of secretory granules in medullary carcinoma may facilitate the establishment of its cell origin.

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Bilateral Phaeochromocytoma Associated with Carcinoma of the Thyroid

Cited by 15 publications

References 3 publications

Bilateral pheochromocytoma associated with papillary adenocarcinoma of the thyroid gland. Report of an unusual case.

Bilateral pheochromocytoma associated with papillary adenocarcinoma of the thyroid gland. Report of an unusual case.

Solid carcinoma of the thyroid gland.Analysis of 53 cases

Pheochromocytoma and medullary carcinoma of thyroid

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