Histological correlates of carotid plaque surface morphology on lumen contrast imaging

Lovett, J K; Gallagher, Peggy A.; Hands, Linda; Walton, J.T.; Rothwell, P M

doi:10.1016/j.accreview.2004.12.138

Cited by 51 publications

(80 citation statements)

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“…Four ulcer shapes-representing each of the four clinically-determined categories defined by Lovett et al [21] (as indicated in parentheses)-were investigated: a hemispherical ulceration (Type I), a mushroom-shaped ulcer incorporating a cavity with a small neck connecting it to the parent vessel lumen (Type II), and ellipsoidal ulcers pointing distally (Type III) and proximally (Type IV).…”

Section: Phantom Designmentioning

confidence: 99%

“…The vessel lumen was defined by the intersection of the geometric primitives with the parametrically defined baseline carotid bifurcation geometry. The dimensions of each ulcer type were designed to be clinically realistic in size, proportions, angle of incidence [9,[21][22][23][24][25], and to maintain a similar cavity volume between ulcers. Each ulcer was incorporated into a carotid vessel geometry at the level of the apex of the bifurcation on the non-flow divider wall, to be consistent with previous characterizations of frequent sites of carotid plaque ulceration [22,24].…”

Section: Phantom Designmentioning

confidence: 99%

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Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

et al. 2009

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The assessment of flow disturbances due to carotid plaque ulceration may provide added diagnostic information to Doppler ultrasound (DUS) of the carotid stenosis, and indicate whether the associated hemodynamics are a potential thromboembolic source. We evaluated the effect of ulceration in a moderately stenosed carotid bifurcation on distal turbulence intensity (TI) measured using clinical DUS in matched anthropomorphic models. Several physiologically relevant ulcer geometries (hemispherical, mushroom-shaped, and ellipsoidal pointing distally and proximally) and sizes (2-mm, 3-mm and 4-mm diameter hemispheres) were investigated. An offline analysis was performed to determine several velocity-based parameters from ensemble-averaged spectral data, including TI. Significant elevations in TI were observed in the post-stenotic flow field of the stenosed carotid bifurcation by the inclusion of ulceration (P < 0.001) in a region two common carotid artery diameters distal to the site of ulceration during the systolic peak and the diastolic phase of the cardiac cycle. Both the size and shape of ulceration had a significant effect on TI in the distal region (P < 0.001). Due to the use of a clinical system, this method provides the means to evaluate for plaque ulcerations in patients with carotid atherosclerosis using DUS.

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Section: Phantom Designmentioning

confidence: 99%

Section: Phantom Designmentioning

confidence: 99%

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

et al. 2009

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“…Like ultrasound, MRI does not expose patients to ionizing radiation and can be repeated as often as required: it enables measurement of plaque burden (area and volume), luminal narrowing and plaque characteristics [33,34]. Additionally, with MRI it is possible to assess the thickness of the fibrous-cap covering a plaque [35] and the extent of the lipid-rich necrotic core (LRNC) [36], (Fig. 2) as well as adventitial neovascularization [37] and intra-plaque hemorrhage [30].…”

Section: Magnetic Resonance Imaging In Clinical Trialsmentioning

confidence: 98%

Non-invasive imaging of atherosclerosis regression with magnetic resonance to guide drug development

et al. 2016

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Slowing of progression and inducing the regression of atherosclerosis with medical therapy have been shown to be associated with an extensive reduction in risk of cardiovascular events. This proof of concept was obtained with invasive angiographic studies but these are, for obvious reasons, impractical for sequential investigations. Non-invasive imaging has henceforth replaced the more cumbersome invasive studies and has proven extremely valuable in numerous occasions. Because of excellent reproducibility and no radiation exposure, magnetic resonance imaging (MRI) has become the non-invasive method of choice to assess the efficacy of anti-atherosclerotic drugs. The high accuracy of this technology is particularly helpful in rare diseases where the small number of affected patients makes the conduct of outcome-trials in large cohorts impractical. With MRI it is possible to assess the extent, as well as the composition, of atherosclerotic plaques and this further enhances the utility of this technology.

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“…In this particular case, the combination of angiographic ulceration and vulnerable morphological features on MRI suggested that the patient was at high risk of subsequent stroke and contributed to the decision to recommend carotid endarterectomy despite only a moderate degree of stenosis (57 %) being present [5,6]. MRI is fast emerging as a robust tool for accurate plaque characterisation [7][8][9].…”

mentioning

confidence: 91%

Correlation of shear stress with carotid plaque rupture using MRI and finite element analysis

U.-King-Im

Trivedi

et al. 2005

J Neurol

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Histological correlates of carotid plaque surface morphology on lumen contrast imaging

Cited by 51 publications

References 0 publications

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: a matched model study

Non-invasive imaging of atherosclerosis regression with magnetic resonance to guide drug development

Correlation of shear stress with carotid plaque rupture using MRI and finite element analysis

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