Histological changes secondary to wire coil placement in breast tissue and lymph nodes

Pinilla-Pagnon, Ignacio; Pérez-Míes, Belén; Reguero, Maria Eugenia; Martinez, Marco-Tulio; Chiva, Miguel; Pérez-Rodrigo, S.; Illarramendi, Odile Ajuria; Martín, María Eugenia; Collado, María Vicenta; Sánchez, M. C.; Rosa-Rosa, Juan Manuel; Palacios, José

doi:10.1007/s00428-018-2399-9

Cited by 2 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They have been rarely reported as an incidental finding in subcapsular location of sentinel nodes from patients in which a previous breast biopsy was performed [1-3]. The tissue damage induced in the tumor and surrounding normal breast tissue by biopsy or wire coil placement results in secondary changes including necrosis, hemorrhage, and histocytic response with multinucleation [1-4]. Some are described as foreign body-type MGC accompanied by foamy macrophages [1].…”

Section: Introductionmentioning

confidence: 99%

Cytologic Features of Lipogranulomatous Reaction in an Axillary Sentinel Lymph Node

et al. 2021

View full text Add to dashboard Cite

Introduction: Multinucleated giant cells (MGC) are a rare finding when evaluating axillary sentinel lymph nodes. Some are described as foreign body-type MGC accompanied by foamy macrophages. They have been rarely reported in nodes from patients in which a previous breast biopsy was performed. The tissue damage induced by biopsy results in secondary changes including fat necrosis and hemorrhage that can migrate to axillary nodes. In this report, we illustrate a lipogranulomatous reaction in cytologic samples obtained during a sentinel lymph node examination of a woman previously biopsied because of breast carcinoma. We have found no previous cytologic descriptions and consider it an interesting finding that should be known to avoid diagnostic misinterpretations. Case: A 51-year-old woman underwent mastectomy of the right breast with a sentinel lymph node biopsy at our medical center. One month before, a control mammography revealed suspicious microcalcifications and a vacuum-assisted breast biopsy resulted in a diagnosis of high-grade intraductal carcinoma with comedonecrosis. Surgery with a sentinel lymph node biopsy was performed. The sentinel node was processed as an intraoperative consultation. Frozen sections and air-dried Diff-Quik stained samples were obtained. They showed abundant lymphocytes with MGC and tumoral cells. MGC showed ample cytoplasm with evident vacuoles of variable size. Occasional hemosiderin-laden macrophages were also present. The complete histologic analysis and immunohistochemical studies revealed no malignant cells. Histologic analysis showed, in subcapsular location, occasional MGC phagocyting lipid droplets. Hemosiderin-laden macrophages were a common finding. Conclusion: Lipogranulomas may appear at axillary sentinel lymph nodes because of fat necrosis induced by previous breast biopsy. The most important consideration is not confounding MGC with epithelial cell clusters. This can occur with not well-processed samples, especially if unmounted.

show abstract