Histological categorization of stromal desmoplasia in breast cancer and its diagnostic and prognostic utility

Abstract

The interplay between a tumor and its environment is exemplified by the morphological changes observed in the stroma of human breast cancer. These changes are evident as stromal desmoplastic reaction. This study evaluated the association of these stromal changes with Tumor size, Tumor grade and axillary node status. Histopathological evaluation showed marked correlation of desmoplastic reaction with higher grade and positive nodes were associated with immature desmoplastic reaction (p<0.05) however no association with tumor size was noted. In conclusion, stromal desmoplastic reaction can be potentially utilized to predict the grade and nodal status of patients. Therefore they can used as prognostic indicators and provide supplementary information regarding known adverse prognostic

Tumor Desmoplastic Stroma - Its Utility as A Prognostic Marker for Breast Carcinoma

“…Higher the grade of tumor, the stroma is of immature type. This was in accordance with Mariam shadhan et al [10] This would be useful in predicting the grade of tumor by assessing the pattern of stromal desmoplasia. The same can be applied to core biopsies also and can assess the tumor preoperatively, which would help in planning the treatment.…”

“…In studies done by Mariam shadan et al, there was no significant correlation between tumor size and type of desmoplasia. [10] This study did not show a significant correlation of age of the patient or IHC markers ER, PR, Her2neu and type of desmoplastic stroma. The studies in breast cancer are mainly focused on lymph nodal metastasis, size and grade of tumor.…”

“…[7] The same categorisation was applied to breast cancer by Mariam shadan etal. [10] In the present study statistically signicant correlation was noted in axillary nodal involvement and the grade of desmoplastic stroma. There was increased risk of axillary nodal metastasis with immature stroma.…”

“…This was similar to the study done by Mariam shadan etal. [10] The linear Annals of Pathology and Laboratory Medicine, Vol. 6, Issue 10, October, 2019 arrangement of collagen fibers foster breast cancer cell migration into extra cellular matrix and promote invasion in early stages of cancer.…”

Extramedullary leukemia behaving as solid cancer: clinical, histologic, and genetic clues to chemoresistance in organ sites

“…The desmoplastic bands of collagen between which AML cells line up in single file provide a ‘highway’ toward blood vessels, as is characteristic of invasive lobular breast tumors, both primary and metastatic. The type of desmoplastic response, termed keloid‐like or immature, has been correlated with poor survival in both breast and colorectal cancers . Similar stromal reaction characterizes the metastases of invasive lobular breast cancer in hollow GI organs.…”