Histological Assessment of Thermal Damage in the Brain Following Infrared Neural Stimulation

Chernov, Mykyta M.; Chen, Gang; Roe, Anna Wang

doi:10.1016/j.brs.2014.01.006

Cited by 47 publications

(66 citation statements)

References 20 publications

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“…However, conventional INS incorporating infrared wavelength in the range of 1450 -2200 nm has been in trouble with tissue damage due to strong water absorption [15]. Although tissue damage is different for the stimulation strategy and condition [16], possible tissue damage due to light absorption by a bulk tissue is still existing [15,17]. A visible light is also available [18], but its low skin transparency can restrict the potential for non-or minimally invasive neural stimulation.…”

Section: Introductionmentioning

confidence: 99%

Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation

Eom

Hwang

et al. 2016

Biomed. Opt. Express

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Despite a potential of infrared neural stimulation (INS) for modulating neural activities, INS suffers from limited light confinement and bulk tissue heating. Here, a novel methodology for an advanced optical stimulation is proposed by combining near-infrared (NIR) stimulation with gold nanorods (GNRs) targeted to neuronal cell membrane. We confirmed experimentally that in vitro and in vivo neural activation is associated with a local heat generation based on NIR stimulation and GNRs. Compared with the case of NIR stimulation without an aid of GNRs, combination with celltargeted GNRs allows photothermal stimulation with faster neural response, lower delivered energy, higher stimulation efficiency and stronger behavior change. Since the suggested method can reduce a requisite radiant exposure level and alleviate a concern of tissue damage, it is expected to open up new possibilities for applications to optical neuromodulations for diverse excitable tissues and treatments of neurological disorders. Hollenberg, M.-E. Lee, and E. Haber, "Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines," Circ. Res. 82(8), 845-851 (1998). 37. S. Tandon, N. Kambi, and N. Jain, "Overlapping representations of the neck and whiskers in the rat motor cortex revealed by mapping at different anaesthetic depths," Eur. J. Neurosci. 27(1), 228-237 (2008). 38. M. Brecht, M. Schneider, B. Sakmann, and T. W. Margrie, "Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex," Nature 427(6976), 704-710 (2004).

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Section: Introductionmentioning

confidence: 99%

Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation

Eom

Hwang

et al. 2016

Biomed. Opt. Express

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“…Tissue damage through optical modalities is caused by thermal, mechanical or photochemical effects . In the neural stimulation literature, thermal effects are reported as lesions or ablation of tissues, protein denaturation or microcavitation and stress waves due to photomechanical forces . The exact threshold at which the optically mediated damage to cells occurs can be difficult to define as it depends on a range of factors including exposure time and power, duty cycle, cell type, peak temperature and the rate of thermal diffusion .…”

Section: Biocompatibilitymentioning

confidence: 99%

Biological Considerations of Optical Interfaces for Neuromodulation

Hart

Kameneva

Wise

et al. 2019

Advanced Optical Materials

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“…The safety of INS has been demonstrated both in the peripheral and in the central nervous system, including the nonhuman primate brain. [34][35][36] Safe stimulation parameters have been published and if one is interested in experimenting with other stimulation sequences, very good computer models for estimating the thermal changes of INS are now available. 37 Theoretical modeling and experimental results show that INS requires a change of temperature of the order of a few degrees (and a fraction of a degree in some tissues), values comparable to the temperature changes observed during optogenetic stimulation.…”

Section: Future Of Insmentioning

confidence: 99%

Infrared neural stimulation: a new stimulation tool for central nervous system applications

Chernov

Roe

2014

Neurophoton

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Abstract. The traditional approach to modulating brain function (in both clinical and basic science applications) is to tap into the neural circuitry using electrical currents applied via implanted electrodes. However, it suffers from a number of problems, including the risk of tissue trauma, poor spatial specificity, and the inability to selectively stimulate neuronal subtypes. About a decade ago, optical alternatives to electrical stimulation started to emerge in order to address the shortcomings of electrical stimulation. We describe the use of one optical stimulation technique, infrared neural stimulation (INS), during which short (of the order of a millisecond) pulses of infrared light are delivered to the neural tissue. Very focal stimulation is achieved via a thermal mechanism and stimulation location can be quickly adjusted by redirecting the light. After describing some of the work done in the peripheral nervous system, we focus on the use of INS in the central nervous system to investigate functional connectivity in the visual and somatosensory areas, target specific functional domains, and influence behavior of an awake nonhuman primate. We conclude with a positive outlook for INS as a tool for safe and precise targeted brain stimulation.

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Histological Assessment of Thermal Damage in the Brain Following Infrared Neural Stimulation

Cited by 47 publications

References 20 publications

Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation

Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation

Biological Considerations of Optical Interfaces for Neuromodulation

Infrared neural stimulation: a new stimulation tool for central nervous system applications

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