Histological and Immunohistochemical Study on the Effect of Prenatal Administration of Diclofenac Sodium on Maternal and Neonatal Organs in albino rat

Mokhtar, Hanan E.L; Alabassery, Nadia; Sabry, Rasha

doi:10.21608/zumj.2021.97027.2352

Cited by 2 publications

(4 citation statements)

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“…There was also marked vasodilatation and congestion of both the maternal sinusoids (blood vessels in the mother's part of the placenta) and the fetal capillaries. Many of the trophoblastic cells in the labyrinth zone degenerated when compared to the control group (Mokhtar et al 2023).…”

Section: Placentamentioning

confidence: 86%

“…They showed several vacuolar degenerative changes in the mesenchymal cells of the lung parenchyma and epithelium of the terminal bronchioles. They also showed detachment and disruption of the epithelial lining of the terminal bronchioles, edema, and hemorrhage in the mesenchymal tissue, dispersed blood spots between the mesenchymal tissues, vacuolated cells in the wall of the congested blood vessel next to the bronchiole (Mokhtar et al 2023).…”

Section: Lungmentioning

confidence: 99%

“…The blood capillaries were also markedly dilated and congested. In addition, extensive cytoplasmic vacuolation with nuclear pyknosis of cardiomyocytes and extracellular edema was also observed (Mokhtar et al 2023).…”

Section: Heartmentioning

confidence: 99%

“…In the portal area, the portal vein was markedly dilated and the bile ductules were proliferated. The walls of the bile ductules were also thickened (Mokhtar et al 2023).…”

Section: Livermentioning

confidence: 99%

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Review on Diclofenac Toxicities in Different Organs

Adel Elnashar,

Kamal,

Magdy

et al. 2024

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction:Diclofenac is an over-the-counter (OTC) non-steroidal anti-inflammatory drug (NSAID) that works through non-selective inhibition of the cyclooxygenase (COX) enzyme, thereby inhibiting the release of prostaglandins. Known for its efficacy in alleviating inflammation, pain, and fever symptoms, concerns have arisen regarding the potential toxicity of Diclofenac. Its toxicity can cause a wide variety of adverse effects, ranging from self-limiting side effects that disappear after treatment cessation to an increased risk of death due to cardiovascular diseases and strokes. Determining the threshold dose that distinguishes between mild, self-limiting side effects and more severe adverse effects poses a major challenge in diclofenac toxicity research. Method: This article reviewed various doses and different organ toxicities observed in animal and human studies using diclofenac. Aim: Our objective is to define the toxicities in fourteen organs and organize them into different categories as animal toxicities, human toxicities, and teratogenicity through pathological changes. Conclusion: By searching different databases and collecting the observed toxicities, we have concluded that the primary affected organs are the stomach, liver, and kidney. However, there is limited knowledge on the toxic effects on the brain, heart, lungs, spleen, eye, bone, bone marrow and blood, and testes, while rare available data for the pancreas, bladder, skin, muscle, and uterus.

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Section: Placentamentioning

confidence: 86%

Section: Lungmentioning

confidence: 99%

Section: Heartmentioning

confidence: 99%

“…In the portal area, the portal vein was markedly dilated and the bile ductules were proliferated. The walls of the bile ductules were also thickened (Mokhtar et al 2023).…”

Section: Livermentioning

confidence: 99%

See 2 more Smart Citations

Review on Diclofenac Toxicities in Different Organs

Adel Elnashar,

Kamal,

Magdy

et al. 2024

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Teratogenic effect of 1.3 bis (p-Hydroxyphenyl)urea on Wistar rats (Rattus norvegicus L.)

Satria,

Fauzi,

Harahap

et al. 2024

PHAR

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Pain is a physiological disorder that pregnant women often experience, so they take various medications to relieve the pain. Many pain relievers on the market have teratogenic effects on pregnant women. 1.3 bis(p-Hydroxyphenyl)urea is a modification of p-aminophenol and has analgesic and anti-inflammatory properties and fewer hepatotoxic side effects. However, its safety in pregnant women has not been studied. This research continues our previous research to determine the teratogenic effects on white rat fetuses and toxic effects on pregnant white rats after administering 1.3 bis(p-Hydroxyphenyl)urea. The teratogenic effect test was carried out on pregnant rats divided into five groups with doses of 50, 500 and 1000 mg/kg BW, CMC Sodium 0.5%, and Gabapentin 50 mg/kg BW as the control group. Rats marked as pregnant were given test preparations and observed for toxic symptoms, and then fetal weight, body length, internal malformations and bone malformations were observed surgically. The study showed that administration at 50 and 500 mg/kg BW doses did not have a teratogenic effect. However, at a dose of 1000 mg/kg BW, it causes teratogenic effects characterized by fetal bleeding and bone abnormalities.

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Histological and Immunohistochemical Study on the Effect of Prenatal Administration of Diclofenac Sodium on Maternal and Neonatal Organs in albino rat

Cited by 2 publications

References 0 publications

Review on Diclofenac Toxicities in Different Organs

Review on Diclofenac Toxicities in Different Organs

Teratogenic effect of 1.3 bis (p-Hydroxyphenyl)urea on Wistar rats (Rattus norvegicus L.)

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