Histological and Immunohistochemical Features of Normal Histiocytes and Langerhans Cells, and Histiocytic Sarcomas in Four-Toed Hedgehogs (Atelerix albiventris)

Son, Nguyen Vu; Chambers, James K.; Dung, Le Thi Kim; Kishimoto, T.; Nishimura, Mitsuyo; Kita, Chiaki; Takada, Yoshi; Miwa, Yoshiyuki; Nakayama, Hiroyuki; Uchida, Kazuyuki

doi:10.1016/j.jcpa.2020.06.009

Cited by 11 publications

(17 citation statements)

References 26 publications

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“…Tumor location and biological behavior were different between the two types, and round-polygonal cell type often showed a disseminated form and worse prognosis than spindle cell type. A localized form occurred mainly in the skin, and spindle cell type was confirmed more frequently in skin than in visceral organs, consistent with the previous study [21]. The primary sites of a disseminated form were mainly observed in the spleen or lymph nodes, which was a different tendency from the previous study [21].…”

Section: Discussionsupporting

confidence: 87%

“…The present study reports for the first time the expression of CD163 in tissues of four-toed hedgehogs. Based on these results, histiocytic sarcoma of four-toed hedgehogs has features of macrophages, as a previous study indicated [21].…”

Section: Discussionsupporting

confidence: 69%

“…In four-toed hedgehogs, HLA-DR has higher reactivity to epidermal Langerhans cells and dermal dendritic cells in the skin than to dendritic cells and macrophages in visceral organs. Therefore, in this species, histiocytic sarcoma in the skin may originate from epidermal Langerhans cells or dermal dendritic cells, as suggested by one study [21].…”

Section: Discussionmentioning

confidence: 75%

“…However, most are single or case series-based reports [10,16,17]. A single comprehensive study including clinical, histopathological, and immunohistochemical features of this tumor has recently been reported [21]. In the present study, the clinical and histopathological features of histiocytic sarcoma were examined in 17 four-toed hedgehogs, and the immunohistochemical efficacy of various antibodies for histiocytes was evaluated.…”

Section: Introductionmentioning

confidence: 94%

“…There are a few reports of histiocytic sarcoma in four-toed hedgehogs [10,16,17,21]. However, most are single or case series-based reports [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (<i>Atelerix albiventris</i>): A retrospective study

2021

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Histiocytic sarcoma was investigated histopathologically and immunohistochemically in 17 four-toed hedgehogs ( Atelerix albiventris ), along with a review of their clinical data. Cases were histopathologically classified into two types: round-polygonal cell type (6 cases) and spindle cell type (11 cases). Round-polygonal cell type was found in visceral organs such as the spleen, lymph nodes, and more, and most cases of this type were consistent with disseminated histiocytic sarcoma. On the other hand, spindle cell type occurred mainly in skin, and almost all cases were consistent with localized histiocytic sarcoma. The prognosis of patients with round-polygonal cell type appeared worse than that of spindle cell type. Immunohistochemically, neoplastic cells of spindle cell type showed stronger reactivity against human leukocyte antigen-DR than round-polygonal cell type. Neoplastic cells of all cases showed strong reactivity against ionized calcium-binding adapter molecule-1 (Iba-1) and various reactivities against cluster of differentiation (CD) 204. Regardless of morphological classification, most tumor cells were negative for CD163, suggesting that this marker is less effective for the diagnosis of histiocytic sarcoma. The results of this study suggest that Iba-1 is the most effective marker for histiocytic sarcoma.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 94%

“…There are a few reports of histiocytic sarcoma in four-toed hedgehogs [10,16,17,21]. However, most are single or case series-based reports [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (<i>Atelerix albiventris</i>): A retrospective study

2021

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Mammalian Cytodiagnosis

2022

Exotic Animal Hematology and Cytology

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Clinicopathologic, immunohistochemical, and ultrastructural features of histiocytic sarcoma in a chinchilla (Chinchilla lanigera)

Enomoto¹,

Tsutsumitani²,

Asakawa³

2021

Veterinary Medicine & Sci

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A 9-year-old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number. Cytology of the nodules revealed sheets of pleomorphic round cells that were morphologically most compatible with histiocytic sarcoma. Histologically, the nodules were fairly demarcated, partially infiltrative, densely cellular neoplasm, and was composed of pleomorphic large round cells arranged in sheets. Special stains for bacteria (Gram stain and Ziehl-Neelsen stain) and fungi (periodic acid-Schiff stain) were all negative. On immunohistochemistry, the neoplastic cells showed strong cytoplasmic positivity for Iba-1 and CD204, but were negative for CD3 and CD20. Transmission electron microscopy failed to detect Birbeck's granules in the cytoplasm of the neoplastic histiocytes. The chinchilla received chemotherapy with lomustine but died spontaneously on day 62 despite treatment. Autopsy with histopathologic examination revealed disseminated histiocytic sarcoma involving the bone marrow, bronchial lymph nodes, nasal cavity, lung, heart, stomach, pancreas, pancreatic lymph nodes, liver, spleen, and kidney. To the best of our knowledge, this is the first report of disseminated histiocytic sarcoma in chinchillas.

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Histological and Immunohistochemical Features of Normal Histiocytes and Langerhans Cells, and Histiocytic Sarcomas in Four-Toed Hedgehogs (Atelerix albiventris)

Cited by 11 publications

References 26 publications

Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (<i>Atelerix albiventris</i>): A retrospective study

Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (<i>Atelerix albiventris</i>): A retrospective study

Mammalian Cytodiagnosis

Clinicopathologic, immunohistochemical, and ultrastructural features of histiocytic sarcoma in a chinchilla (Chinchilla lanigera)

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