1998
DOI: 10.1016/s0923-1811(97)00077-7
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Histological and immunocytochemical studies of human psoriatic lesions transplanted onto SCID mice

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Cited by 25 publications
(20 citation statements)
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“…Recent establishment of the SCID-human skin chimeras with transplanted psoriasis plaques has opened new vistas to study the molecular complexities involved in psoriasis (Nickoloff et al, 1995). Histologic and immunologic features of psoriasis can be maintained in the transplanted plaques for more than 3 mo (Gilhar et al, 1997;Sugai et al, 1998) and our experience is that these features are maintained for more than 6 mo. In this study, we have demonstrated that K252a, an inhibitor of signal transductions induced by NGF/NGF-R interaction, is therapeutically effective in psoriasis.…”
Section: Discussionmentioning
confidence: 79%
“…Recent establishment of the SCID-human skin chimeras with transplanted psoriasis plaques has opened new vistas to study the molecular complexities involved in psoriasis (Nickoloff et al, 1995). Histologic and immunologic features of psoriasis can be maintained in the transplanted plaques for more than 3 mo (Gilhar et al, 1997;Sugai et al, 1998) and our experience is that these features are maintained for more than 6 mo. In this study, we have demonstrated that K252a, an inhibitor of signal transductions induced by NGF/NGF-R interaction, is therapeutically effective in psoriasis.…”
Section: Discussionmentioning
confidence: 79%
“…In fact, single-cell suspensions are rapidly recognized and lysed by mice NK cells (Meyerrose et al, 2003). However, in SCID mice, grafts of solid tissues are well tolerated and psoriatic characteristics are maintained for several months in the transplantations involving psoriatic skin Takizawa et al, 1995 (Sugai et al, 1998). In this latter study, the psoriatic phenotype was well maintained but the histological and immunohistochemical characteristics gradually disappeared as lymphocytic infiltration of the psoriatic lesion declined.…”
Section: Xenotransplantationmentioning
confidence: 70%
“…+ (Hansson, et al, 2002) Xenotransplantation Athymic nude mouse + + ? - (Fraki, et al, 1983;Krueger, et al, 1981) SCID + + + + (Boehncke et al, 1994;Gilhar, et al, 1997;Nickoloff et al, 1995;Sugai, et al, 1998;Takizawa, et al, 1995) AGR129 + + + + (Boyman, et al, 2004) …”
Section: Spontaneous Mutationmentioning
confidence: 99%
“…Moreover, after 22 weeks of grafting, apart from persistence of acanthosis and hyperkeratosis there was resolution of Munro's microabscesses, loss of parakeratosis, and decrease in lymphocytic infiltrates in the transplanted grafts. [64] However, in transplanted grafts, all the pathological features of psoriasis could be maintained longer by intradermal or intravenous administration of T cells derived from psoriatic plaques, but not from peripheral blood mononuclear cells (PBMCs). [64] Interestingly, injection of autologous immunocytes activated with Staphylococcus enterotoxins (SEB and SEC2) and IL-2 into non-lesional skin grafts from psoriatic patients induced immunological as well as histopathological features of psoriasis.…”
Section: Exploring Pathogenesis Of Psoriasismentioning
confidence: 99%
“…[64] However, in transplanted grafts, all the pathological features of psoriasis could be maintained longer by intradermal or intravenous administration of T cells derived from psoriatic plaques, but not from peripheral blood mononuclear cells (PBMCs). [64] Interestingly, injection of autologous immunocytes activated with Staphylococcus enterotoxins (SEB and SEC2) and IL-2 into non-lesional skin grafts from psoriatic patients induced immunological as well as histopathological features of psoriasis. [47,48] In another study, administration of PBMC, stimulated by superantigen (staphylococcal superantigen exfoliative toxin) into non-lesional psoriatic skin resulted in histopathological features of psoriasis as well as infiltrates of CD3 positive cells expressing cutaneous lymphocyte associated antigen.…”
Section: Exploring Pathogenesis Of Psoriasismentioning
confidence: 99%