Histological analysis of 41 dentigerous cysts in a paediatric population

Abstract

The current study provides increased knowledge of the histological features of dentigerous cysts in a large retrospective series of paediatric patients and provides further evidence regarding the frequency of inflammatory dentigerous cysts.

Dentigerous Cyst in the Maxillary Anterior Region of a Pediatric Patient

“…This is the age in which the permanent canines and premolars have their greatest eruptive potential and the widening of dental follicle is a part of the eruptive process. 6 Dentigerous cysts in the pediatric group commonly occur in the late mixed dentition period, as there is increased probability of impaction of the maxillary canines and of periapical inflammation from a nonvital deciduous tooth spreading to involve the follicle of an unerupted permanent succedaneous tooth.…”

Multiple Dentigerous Cysts: two case reports of nonsyndromic twins

“…1 They may involve impacted, unerupted permanent teeth, supernumerary teeth and odontomas, and rarely involve deciduous teeth. 3,6,11 The origin of DCs has been partially attributed to PTCH gene inactivation in a progenitor cell of the enamel organ. 13 Some authors believe that PTCH alterations are necessary and may be the event that triggers the formation and growth of various cysts.…”

“…1 DCs are thought to result from the proliferation of the reduced enamel epithelium (REE) shortly after enamel formation during dental tissue development. 2,3 The DC may partially or completely involve the crown of an unerupted tooth, and be attached to the tooth at the cement-enamel junction. 2,3 Degeneration of the stellate reticulum, accumulation of fluid between the layers of REE, diminished adherence of REE, and monoclonal proliferation in the REE through altered protein patched homolog (PTCH) signaling in the primary cilium have been suggested to explain the pathogenesis of DC.…”

“…2,3 The DC may partially or completely involve the crown of an unerupted tooth, and be attached to the tooth at the cement-enamel junction. 2,3 Degeneration of the stellate reticulum, accumulation of fluid between the layers of REE, diminished adherence of REE, and monoclonal proliferation in the REE through altered protein patched homolog (PTCH) signaling in the primary cilium have been suggested to explain the pathogenesis of DC. 4 It is estimated that 1.4 DCs are found for every 100 unerupted teeth.…”

“…6 Over 95% of DCs are single lesions. 3,5 Multiple occurrences of DC have been described in mucopolysaccharidosis (Maroteaux-Lamy and Hunter's syndrome). 7,8 Moreover, the association of multiple DCs with other syndromes, such as cleidocranial dysplasia and basal cell nevus syndrome, has been poorly documented in the literature.…”