Histologic Variations in the Structure of Human Eccrine Sweat Glands

Holyoke, John B.; Lobitz, Walter C.

doi:10.1038/jid.1952.18

Cited by 71 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Les groupes pilaires, habituellement bien identifiables chez l'enfant [22], sont ici particulièrement apparents, mais il s'agit le plus souvent de «Vierhaargruppen», ce qui est une éventualité plus rare sur la peau normale [21]. Le dédoublement des conduits sudorifères est une anomalie qui n'a été signalée que par Holyoke et Lobitz [9], mais en dehors du contexte de Y LP.…”

Section: Discussionunclassified

Incontinentia pigmenti achromians(ITO)

Grosshans¹,

Stoebner²,

Bergoend³

et al. 1971

Dermatology

View full text Add to dashboard Cite

Four new cases of Iτo’s Incontinentia pigmenti achromians developing in 1 family, the mother and her 3 daughters, are reported by the authors. Histopathological investigations of the skin show an irregular epidermic hypochromy without pigment loss in the upper dermis, decrease and morphological immaturity of melanocytes, disturbance of keratinization with growth of large clear cells and malformation of skin appendages. The pathological correlations of I. P. achromians (Iτo) and histopathological pecularities are similar to those of I. P. (Bloch-Sulzberger).

show abstract

Section: Discussionunclassified

Incontinentia pigmenti achromians(ITO)

Grosshans¹,

Stoebner²,

Bergoend³

et al. 1971

Dermatology

View full text Add to dashboard Cite

show abstract

“…The hair follicle stem cells are specified in the earliest stages of hair follicle morphogenesis and later give rise to sebaceous gland stem cells [shown in mice: (Nowak et al 2008)]. It is assumed that eccrine sweat glands are maintained by their own stem cell populations as well, although human bodily eccrine sweat glands are remarkably devoid of mitosis in basal conditions, suggesting an extremely low cell turnover [shown in humans: (Holyoke and Lobitz 1952;Lobitz et al 1954;Rittié et al 2013aRittié et al , 2016]. However, this turnover dramatically increases upon wounding [shown in humans: (Lobitz et al 1954;Rittié et al 2013aRittié et al , 2016] or in eccrine sweat glands of skin located near surgical sites (Morimoto and Saga 1995).…”

Section: Skin Epithelial Adult Stem Cellsmentioning

confidence: 99%

Cellular mechanisms of skin repair in humans and other mammals

Rittié

2016

J. Cell Commun. Signal.

241

167

View full text Add to dashboard Cite

The increased incidence of non-healing skin wounds in developed societies has prompted tremendous research efforts on the complex process known as Bwound healing^. Unfortunately, the weak relevance of modern wound healing research to human health continues to be a matter of concern. This review summarizes the current knowledge of the cellular mechanisms that mediate wound closure in the skin of humans and laboratory animals. The author highlights the anatomical singularities of human skin vs. the skin of other mammals commonly used for wound healing research (i.e. as mice, rats, rabbits, and pigs), and discusses the roles of stem cells, myofibroblasts, and the matrix environment in the repair process. The majority of this review focuses on reepithelialization and wound closure. Other aspects of wound healing (e.g. inflammation, fibrous healing) are referred to when relevant to the main topic. This review aims at providing the reader with a clear understanding of the similarities and differences that have been reported over the past 100 years between the healing of human wounds and that of other mammals.

show abstract

“…8 There is some conflict as to whether they are PAS (mucin) positive 6 or negative. 1,8 Alcian blue (mucopolysaccharide) and Berlin blue (iron) stains are reported to be negative. 8 Electron microscopy has not been able to shed any further light on the contents of these vacuoles.…”

Section: Discussionmentioning

confidence: 96%

“…8 It has been noted to be present in all eccrine glands in the same patients and remains present over time. 1,6 This enigmatic entity is of uncertain clinical significance. It has been noticed as an incidental finding present in skin biopsies from a range of anatomical sites in patients with a host of different dermatological conditions.…”

Section: Discussionmentioning

confidence: 98%

Clear Cell Change in Eccrine Glands Is Not Associated With Diabetes

Cherian

Beer²

2010

The American Journal of Dermatopathology

View full text Add to dashboard Cite

The significance of clear cell change (clear reticulated cytoplasmic change) in the secretory portion of eccrine glands remains an enigma. It has been postulated to be a product of defective cellular glucose metabolism and potentially a predictor of diabetes. A series of 61 specimens from 38 patients were assessed to establish any demographic, seasonal, or metabolic associations. Sixty-one specimens from 38 patients with eccrine clear cell changes were identified prospectively by one of the authors (T.W.B.). Each specimen was stratified by site, age, sex, and season. For each patient, the general practitioner was contacted and diabetes status was ascertained. This was possible in 34 of 38 patients. Fifty routine consecutive cases from the archive in both summer and winter were studied for possible clear cell changes, looking for any seasonal variance. No clear association between the presence of eccrine clear cell change and any demographic or seasonal pattern was found. Specifically, there did not seem to be any significant association between diabetes and this histological finding. The prevalence of diabetes in cases with eccrine clear cell change was similar to the background population prevalence of diabetes in Australia (7.9% vs. 7.4%). The incidence of this finding is approximately 1 case in 189 specimens (0.5%) examined in this practice. Clear cell change within the secretory portion of eccrine glands seems to be an incidental finding, with no clear clinicopathological implication. In particular, there does not seem to be any association with diabetes.

show abstract

Histologic Variations in the Structure of Human Eccrine Sweat Glands

Cited by 71 publications

References 26 publications

Incontinentia pigmenti achromians(ITO)

Incontinentia pigmenti achromians(ITO)

Cellular mechanisms of skin repair in humans and other mammals

Clear Cell Change in Eccrine Glands Is Not Associated With Diabetes

Contact Info

Product

Resources

About