“…This could be related to the fact that some syringomas have been reported to express progesterone receptors, thus being more frequent in women during puberty or pregnancy. 8 However, PCCH involves the eccrine duct, and thus might be considered a different entity, not related to the clear cell changes observed in the secretory portion of the gland. 6 The clear cell changes seen in this condition, and in CCS, seem to be caused by a glycogen deposition in the cytoplasm of the cells that comprise of the eccrine duct.…”