Histologic variants of infiltrating lobular carcinoma of the breast

Fechner, Robert E.

doi:10.1016/s0046-8177(75)80099-2

Cited by 119 publications

(42 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2, C-D), similar to the alveolar variant of lobular carcinoma (23). A homogeneous population of large clear cells, with faintly granular periodic acid-Schiff-negative cytoplasm, formed these NE alveolar carcinomas.…”

Section: Histotypes Of Ne Breast Carcinomasmentioning

confidence: 74%

Expression of Apocrine Differentiation Markers in Neuroendocrine Breast Carcinomas of Aged Women

et al. 2001

View full text Add to dashboard Cite

Neuroendocrine (NE) breast carcinomas are a rare entity in young women; however, their frequency increases in aged patients. The present work demonstrates that NE breast carcinomas in elderly women can also express an apocrine immunophenotype and analyzes the histological and clinical aspects of such differentiation. A selected series of 50 NE tumors (positive for NE markers in >50% of the cells) was tested for the immunocytochemical expression of gross cystic disease fluid protein-15 (GCDFP-15). The results demonstrated that about 50% of moderately (G2) and well-differentiated (G1) NE breast carcinomas (mucinous, solid papillary, and solid cohesive histotypes) coexpressed the apocrine marker. In these cases, specific mRNA for GCDFP-15 (PIP) and for chromogranin A (ChA) was demonstrated using in situ hybridization (ISH). Carcinomas of the alveolar subtype (G2) and poorly differentiated carcinomas (G3), including one case of atypical carcinoid, were pure NE carcinomas, devoid of apocrine differentiation. The steroid receptor status of these lesions was evaluated to test a possible involvement of androgen receptors in apocrine differentiation. We demonstrated that the level of AR and the mean age of patients at diagnosis were significantly higher in apocrine than in nonapocrine differentiated tumors. The histological grade and the expression of estrogen receptor (ER) significantly influenced the prognosis of these NE carcinomas, either pure or NE-apocrine differentiated. The most original result of our study is therefore the demonstration of a possible divergent apocrine differentiation of NE breast carcinomas that might be regulated by the activation of androgen receptors in elder patients. In addition, the possibility for using Chs or GCDFP-15 serum values in the follow-up of these patients, as demonstrated in two cases of the present series, can justify the immunophenotyping of the tumors.

show abstract

Section: Histotypes Of Ne Breast Carcinomasmentioning

confidence: 74%

Expression of Apocrine Differentiation Markers in Neuroendocrine Breast Carcinomas of Aged Women

et al. 2001

View full text Add to dashboard Cite

show abstract

“…These include, the solid variant, 10 the alveolar variant, 3 the tubulo-lobular variant, 11 the signet ring variant, 12 the histiocytoid variant 13 and a mixed subgroup. 12 The mixed subgroup, in Dixon et al's 12 original paper, was recognized when an invasive lobular carcinoma was comprised of a mixture of variants or when the invasive lobular carcinoma had a classic growth pattern, but the degree of nuclear pleomorphism was greater than that seen in the classic subgroup.…”

Section: Discussionmentioning

confidence: 99%

Invasive lobular carcinoma: to grade or not to grade

et al. 2005

View full text Add to dashboard Cite

Grading of invasive ductal carcinoma of no special type using the Nottingham combined histologic grading system provides independent prognostic information. The prognostic utility of grading invasive lobular carcinomas, however, has not been fully elucidated. In addition, the relationship between grade in invasive lobular carcinomas and expression of predictive biomarkers is less certain. The purpose of this study was to correlate histologic grade in invasive lobular carcinoma with known prognostic and predictive markers. All primary resections for invasive mammary carcinomas diagnosed in Mount Sinai Hospital, Toronto, between the years 1996 and 2002 were reviewed (n ¼ 1053). Of these cases, 50 were pure invasive lobular carcinoma (incidence 4.7%). The median age at diagnosis was 64 years. These tumors were graded using the Nottingham combined histologic grading system and analyzed for estrogen receptor, progesterone receptor, HER2/neu and E-cadherin expression. Tumor grade was correlated with tumor size (P ¼ 0.03), and the American Joint Committee on Cancer nodal status (P ¼ 0.05). Assessment of the individual components of grade showed that the mitotic score was highly correlated with tumor size (P ¼ 0.02), lymph node positivity (P ¼ 0.02) and overall American Joint Committee on Cancer stage (P ¼ 0.01). Estrogen receptor and progesterone receptor were highly expressed irrespective of the grade of tumor. HER2/neu protein overexpression and E-cadherin protein expression was absent in all invasive lobular carcinomas studied. We conclude that pure invasive lobular carcinoma is uncommon and occurs predominantly in postmenopausal women. Increasing tumor grade is correlated with median tumor size and the American Joint Committee on Cancer nodal stage, but not correlated with the expression of estrogen receptor, progesterone receptor, E-cadherin or HER2/neu protein overexpression.

show abstract

“…Solid fillings of ducts may occur, and typical ILC may quite frequently exist in combination with other types of invasive carcinoma (Fisher et al, 1975). Moreover, several variants of ILC that differ from the classical form have been described: the solid or confluent variant (Fechner, 1975), the tubulolobular variant (Fisher et al, 1977) and trabecular and alveolar variants (Martinez and Azzopardi 1979). The variant patterns usually exist only in a modest proportion of the whole tumour volume, and they are rarely the dominant feature (Dixon et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

“…All hospitals, practising physicians and pathological laboratories are requested to report to (WHO, 1981). ILCs were categorized as either 'classical' (n = 157) or 'variant' forms (n = 60) using the criteria published previously (Fechner, 1975;Fisher et al, 1977;Martinez and Azzopardi, 1979 DNA flow cytometry DNA ploidy of 637 carcinomas had been determined by flow cytometry as described previously in conjunction with another study of paraffin-embedded tissue (Toikkanen et al, 1989). The Table 2.…”

Section: Patient Identification and Follow-upmentioning

confidence: 99%

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Toikkanen

Pylkkänen²,

Joensuu³

1997

Br J Cancer

142

105

View full text Add to dashboard Cite

Invasive lobular carcinoma of the breast has better short-and long-term survival than invasive ductal carcinoma S Toikkanen', L Pylkkanen2and H Joensuu3Departments of 'Pathology and 2Oncology, University Central Hospital of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland; 3Department of Oncology, University Central Hospital of Helsinki, Haartmaninkatu 4, Helsinki, Finland Summary The outcome and prognostic factors of 217 women with invasive lobular carcinoma (ILC) and those of 1121 women with invasive ductal carcinoma (IDC) of the breast were compared. The patients were followed up for 10-43 years. Women with ILC had axillary nodal metastases less frequently than those with IDC (43% vs 53%, P= 0.02), although there was no difference in the primary tumour size between the groups. ILCs were more frequently of low grade, had lower mitotic counts and had less tumour necrosis. Furthermore, ILCs had lower Sphase fractions and were more often DNA diploid in flow cytometric analysis than IDCs (P < 0.0001 for all comparisons). The 5-and 30-year corrected survival rates of women with ILC were 78% and 50%, respectively, compared with 63% and 37% for women with IDC (P = 0.001). Small pTl NOMO ILCs (n = 41) had 100% 1 0-year and 83% 20-year corrected survival rates. In a multivariate analysis, a large primary tumour size, the presence of axillary nodal metastases, a high mitotic count and the presence of tumour necrosis all had an independent prognostic value in ILC. We conclude that ILC is associated with better survival than IDC.

show abstract

Histologic variants of infiltrating lobular carcinoma of the breast

Cited by 119 publications

References 7 publications

Expression of Apocrine Differentiation Markers in Neuroendocrine Breast Carcinomas of Aged Women

Expression of Apocrine Differentiation Markers in Neuroendocrine Breast Carcinomas of Aged Women

Invasive lobular carcinoma: to grade or not to grade

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Contact Info

Product

Resources

About