Histologic Study of Depressed Acne Scars Treated with Serial High-Concentration (95%) Trichloroacetic Acid

YUG, ANTHONY; Lane, Joshua E.; Howard, Michael S.; Kent, David

doi:10.1111/j.1524-4725.2006.32220.x

Cited by 34 publications

(37 citation statements)

References 8 publications

(19 reference statements)

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“…But this lesser response after more sessions was probably due to the fact that they had used 65% TCA whereas we had used 100% TCA in our study resulting in better percentage improvement scores. 5,14 We observed that among the different types of scars box scars and rolling scars responded well to microneedling therapy whereas the icepick scars responded well to CROSS technique. Same was seen in the study by Neerja.…”

Section: Discussionmentioning

confidence: 70%

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Dhollan

Thirunavukkarasu

2017

Int J Res Dermatol

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Background: Acne scars are a cause of major psychological morbidity in the young population. Microneedling using dermarollers which uses the principle of percutaneous collagen induction and Chemical reconstruction of skin scars (CROSS) using Trichloroacetic acid (TCA) are both widely used methods for the treatment of acne scars and are cheaper alternatives to LASER resurfacing. The aim of our study is to objectively compare the efficacy of microneedling using dermaroller with CROSS using 100% TCA in the management of acne scars.Methods: 30 patients with acne scars were divided into 2 groups A and B with 15 patients each. Group ‘A’ underwent microneedling using 1.5 mm dermaroller and Group ‘B’ underwent CROSS technique with 100% TCA. A total of 4 sessions at monthly intervals were performed on both groups. The percentage improvement in the acne scar grade between the two groups was compared using the student ‘t’ test.Results: Among the 30 patients, 13 (86%) patients in Group A (Microneedling) and 11 (78%) patients in group B (CROSS) noted significant reduction in their acne scar grade. The difference between the 2 groups was statistically insignificant. 3 patients had significant post inflammatory hyperpigmentation in group ‘B’.Conclusions: The techniques of microneedling and CROSS are both effective in acne scars But microneedling scores in other aspects such as faster wound healing, better skin rejuvenation and safety in dark skinned individuals.

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Section: Discussionmentioning

confidence: 70%

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Dhollan

Thirunavukkarasu

2017

Int J Res Dermatol

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“…Scar improvement involves collagen remodeling, including breaking old collagen strands and inducing collagen growth. Chemical peeling with TCA increases collagen fiber density and elastic fiber fragmentation [24].…”

Section: Discussionmentioning

confidence: 99%

Microneedling system alone versus microneedling system with trichloroacetic acid in the management of abdominal striae rubra

Sanad¹,

Aginaa²,

Sorour³

2015

Journal of the Egyptian Womenʼs Dermatologic Society

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BackgroundStriae distensae or stretch marks, although not a health risk, are of significant cosmetic concern as it affects the patient's psychological condition. Although many treatment modalities have been attempted with variable results, there is no standard treatment modality for it. Objective To compare the efficacy of a microneedling system (dermaroller) when used alone or combined with 15-30% trichloroacetic acid (TCA) in the management of striae rubra. Patients and methodsThis clinical trial included 30 female patients with abdominal striae rubra treated with a dermaroller alone on the left side of the abdomen (GI) and with a dermaroller + 15-30% TCA on the right side of the abdomen (GII). Patients were treated for six sessions at 3-week intervals. We assessed the clinical features (length, width, color, and texture) of striae in each group at every session and 3 weeks after the end of the sessions (follow-up). The response to treatment was assessed objectively by the treating physicians and skin biopsies stained with hematoxylin and eosin and picrosirius red stains. Subjective assessment of the clinical photographs and patient satisfaction scores was carried out by two uninvolved blind dermatologists at every session. Results A comparison between GI and GII at the follow-up session revealed statistically significant differences in length (P = 0.002), width (Po0.001), color, and texture (P = 0.049 and 0.041, respectively). More improvement in the striae was noted in GII, as 19 (63.3%) patients showed good to excellent improvement compared with 10 (33.3%) patients in GI. Skin biopsies in GII showed increased epidermal thickness after treatment (Po0.005). Collagen content was increased after treatment in both groups. Side effects including transient erythema, edema, burning pain, and hyperpigmentation were observed more in GII with increasing concentration of TCA peeling. ConclusionBoth dermaroller and dermaroller + 15-30% TCA are effective treatment modalities for striae rubra. However, dermaroller + 15-30% TCA gives better results and dermaroller alone has fewer side effects.

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“…According to several authors [39][40][41] CROSS technique has high efficacy in the case of few isolated scars on healthy skin. TCA is applied for a few seconds by a wooden applicator until the scar displays a white frosting.…”

Section: Trichloroacetic Acidmentioning

confidence: 99%

The Management of Atrophic Acne Scars: Overview and New Tools

Fabbrocini¹

2013

J Clin Exp Dermatol Res

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Histologic Study of Depressed Acne Scars Treated with Serial High-Concentration (95%) Trichloroacetic Acid

Abstract: Focal application of high-concentration TCA to atrophic and "ice-pick" acne scars appears to produce clinical improvement. Histologic changes of this technique are described.

Cited by 34 publications

References 8 publications

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Microneedling vs. chemical reconstructon of skin scars with trichloroacetic acid: a comparative study

Microneedling system alone versus microneedling system with trichloroacetic acid in the management of abdominal striae rubra

The Management of Atrophic Acne Scars: Overview and New Tools

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