Histologic influence of paclitaxel-eluting covered metallic stents in a canine biliary model

Tracheal Self-Expandable Metallic Stents: A Comparative Study of Three Different Stents in a Rabbit Model

“…In order to explain these findings, we hypothesize that the conditions of a DES differ according to location. The correct drug dosage is also important in order to avoid tissue damage 31 . In another study, high paclitaxel concentration was associated with a worse response in the biliary duct 32 .…”

Outcome of palliative self-expanding metal stent placement in malignant colorectal obstruction according to stent type and manufacturer

“…The drugeluting stent coated with antitumor drug could be anchored more easily, lessening the chance of migration, and prevent reocclusion [22]. Although some studies reported the effect of a stent covered with an antitumor drug-releasing membrane, drug-eluting uncovered stent coated with an antitumor drug deposited the stent surface with or without polymer matrix is not developed in the gastrointestinal tract [23,24]. As various drugs and methods of controlled drug release have been developed in coronary drug-eluting stents [25], new drug-delivery coating system for gastrointestinal tract is expected to be developed in the future technology.…”

Gastrointestinal Stent Update

“…Therefore, it is important to choose a drug in adequate concentrations which can exert antitumor effect without damaging the adjacent normal biliary mucosa. 27 Infection is another arm in complications of metallic biliary stent which is a palliative approach for the treatment of diseases involving various cause of biliary obstruction. Its major limitation is represented by stent occlusion, followed by life-threatening cholangitis.…”