Tracheal Self-Expandable Metallic Stents: A Comparative Study of Three Different Stents in a Rabbit Model

Serrano, C. Sancho; Lostalé, Fernando; Rodríguez-Panadero, Francisco; Blás, Ignacio de; Laborda, Alicia; Gregorio, M.A. de

doi:10.1016/j.arbr.2015.06.012

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…Another promising approach is metallic stents with a drug-eluting coating used in cardiology for many years but there are no commercially available analogs for the trachea. Today, several composite coating options can be used as candidates [ 22 , 23 , 24 , 25 , 26 ]. The electrospun PCL-based coatings for metal stents have excellent mechanical characteristics as reported in [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

et al. 2021

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Expandable metallic stent placement is often the only way to treat airway obstructions. Such treatment with an uncoated stent causes granulation proliferation and subsequent restenosis, resulting in the procedure’s adverse complications. Systemic administration of steroids drugs in high dosages slows down granulation tissue overgrowth but leads to long-term side effects. Drug-eluting coatings have been used widely in cardiology for many years to suppress local granulation and reduce the organism’s systemic load. Still, so far, there are no available analogs for the trachea. Here, we demonstrate that PLA-, PCL- and PLGA-based films with arrays of microchambers to accommodate therapeutic substances can be used as a drug-eluting coating through securely fixing on the surface of an expandable nitinol stent. PCL and PLA were most resistant to mechanical damage associated with packing in delivery devices and making it possible to keep high-molecular-weight cargo. Low-molecular-weight methylprednisolone sodium succinate is poorly retained in PCL- and PLGA-based microchambers after immersion in deionized water (only 9.5% and 15.7% are left, respectively). In comparison, PLA-based microchambers retain 96.3% after the same procedure. In vivo studies on rabbits have shown that effective granulation tissue suppression is achieved when PLA and PLGA are used for coatings. PLGA-based microchamber coating almost completely degrades in 10 days in the trachea, while PLA-based microchamber films partially preserve their structure. The PCL-based film coating is most stable over time, which probably causes blocking the outflow of fluid from the tracheal mucosa and the aggravation of the inflammatory process against the background of low drug concentration. Combination and variability of polymers in the fabrication of films with microchambers to retain therapeutic compounds are suggested as a novel type of drug-eluting coating.

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Section: Introductionmentioning

confidence: 99%

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

et al. 2021

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“…While these concentrations might be adequate to prevent neo‐intimal hyperplasia following intravascular insertion , where blood flow clears a portion of the drug delivered, effective clearing is unlikely to occur in the trachea, as the natural mucociliary clearing mechanism can be impaired by stent insertion. Moreover, the lipophilic nature of paclitaxel might enhance cellular uptake, thereby increasing cytotoxicity with subsequent destruction of the normal epithelium, as we described previously .…”

Section: Discussionmentioning

confidence: 64%

“…The stents were deployed percutaneously under general anaesthesia and fluoroscopic guidance. Computed tomography (CT) tracheal studies were performed under sedation 30 and 90 days after stent deployment as previously published by our Group . Parameters assessed in the CT study were maximum tracheal lumen stenosis in an axial view (%), stenosis length in a sagittal view (mm) and detection of image compatible with granulomas (present or absent).…”

Section: Methodsmentioning

confidence: 99%

Stent‐induced tracheal stenosis can be predicted by IL‐8 expression in rabbits

Arellano-Orden

Serrano

Montes-Worboys

et al. 2016

Eur J Clin Investigation

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“…El conejo es un modelo animal ampliamente empleado en los estudios de la vía aérea. Diversos tipos de prótesis, tanto intraluminales como extraluminales, han sido testadas en este modelo [18][19][20] . En el estudio que se presenta, la técnica empleada fue un éxito en el 100 % de los casos, no produciéndose muertes ni complicaciones graves en ninguno de los 19 animales en los que se realizó, por lo tanto se trata de una técnica segura y reproducible.…”

Section: Discussionunclassified

Implantación de stents biodegradables traqueales en animal de experimentación. Descripción de la técnica

Rodríguez-Zapater,

López-Minguez,

Bonastre

et al. 2019

INTERV

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Tracheal Self-Expandable Metallic Stents: A Comparative Study of Three Different Stents in a Rabbit Model

Abstract: Introduction

Cited by 13 publications

References 33 publications

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

Stent‐induced tracheal stenosis can be predicted by IL‐8 expression in rabbits

Implantación de stents biodegradables traqueales en animal de experimentación. Descripción de la técnica

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