Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

Abstract

This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (β-TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% ± 9.09% and 26.92% ± 7.26% and residual graft particle areas of 23.13% ± 6.16% and 32.25% ± 8.48% in the MPM and β-TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and β-TCP groups were 41.48% ± 8.41% and 40.83% ± 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the β-TCP and MPM groups were 17.12% ± 13.55% and 14.41% ± 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and β-TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures

Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

“…As regard to bone density, results of the present study is in accordance with Sultan et al and Elbokle et al , they found that MPM give successful results regarding bone density (26,27) . Also in agreement with Cinar et al who found that MPM, could increase new bone formation (28) .…”

Evaluation of Mineralized Plasmatic Matrix Versus Platelet Rich Plasma in Deficient Anterior Maxillary Alveolar Ridge: A Randomized Controlled Clinical Trial

“…This result supports that MPM has a greater impact on bone quality when compared with the first generation plasma derivative PRP. This coincides with the clinical and histological study conducted by Cinar el al 21 in which they compared maxillary sinus augmentation using MPM in one group versus beta tricalcium calcium phosphate in the other group. They concluded that the fibrin bound MPM showed better bone formation in terms of quantity and quality then beta tricalcium phosphate used alone.…”

Morphometric and histomorphometric evaluations of high-purity macro/microporous beta-tricalcium phosphate in maxillary sinus floor elevation: preliminary results on a retrospective, multi-center, observational study

“…For the volume of the maxillary grafted materials or the mixture of both the maxillary grafted materials and the newly formed bone after the maxillary sinus floor elevation, the volume of the maxillary grafted materials or the mixture of both the maxillary grafted materials and the newly formed bone drawn by the volume rendering method was calculated (Fig. 4) [26,27].…”