Evaluation of Mineralized Plasmatic Matrix Versus Platelet Rich Plasma in Deficient Anterior Maxillary Alveolar Ridge: A Randomized Controlled Clinical Trial

Abstract

Introduction: Plasma derivatives have been used widely in the field of dental implantology since the introduction of the first generation platelet rich plasma (PRP) to enhance both soft tissue and bone formation. Recently, mineralized plasmatic matrix (MPM) has introduced the advantage of encasing both the bone graft and the required growth factors in a fibrin meshwork that can maintain its form while enhancing bone formation.Objective: is to clinically and radiographically evaluate the effect of platelet rich plasma mixed with bone graft versus mineralized plasmatic matrix on peri-implant bone formation and osseointegration. Materials and Methods:Sixteen patients with missing anterior teeth were included in the study and divided into two groups; in group A, MPM was placed simultaneously with delayed implant placement while in group B, PRP mixed with biphasic calcium phosphate bone graft and a collagen membrane were used to cover the dehiscence after implant placement. Patients were followed up clinically and radiographically for 9 months to assess implant stability and labial bone thickness and density.Results: Regarding implant stability, there was no significant difference between the 2 groups. However, when it comes to labial bone thickness and the change in labial bone density, there was a statistically significant difference between the two groups in favour of the MPM group. Conclusion:MPM is a cohesive meshwork of bone graft, fibrin and growth factors achieving better bone formation in terms of quantity and quality when compared with the first generation plasma derivative PRP mixed with biphasic calcium phosphate.