Histologic grade is an independent prognostic factor for survival in non–small cell lung cancer: An analysis of 5018 hospital- and 712 population-based cases

Sun, Zhifu; Aubry, Marie Christine; Deschamps, Claude; Marks, Randolph S.; Okuno, Scott H.; Williams, Brent A.; Sugimura, Hiroshi; Pankratz, V. Shane; Yang, Ping

doi:10.1016/j.jtcvs.2005.12.057

Cited by 130 publications

(91 citation statements)

References 22 publications

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“…These factorsespecially poorly differentiated histology 16 -should be considered as inclusion criteria for ongoing and future adjuvant trials. Furthermore, subgroup analysis of these adverse clinicopathologic features in meta-analyses of adjuvant NSCLC trials may help identify high-risk patients with early-stage NSCLC who may be considered for and benefit from adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival of stage I nonsmall cell lung cancer patients

Zell

Ziogas

et al. 2007

Cancer

190

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BACKGROUND. Platinum‐based adjuvant chemotherapy in randomized trials has failed to provide a survival benefit in patients with resected stage I nonsmall cell lung cancer (NSCLC). Using data from the California Cancer Registry (CCR), we explored factors that had detrimental effects on survival in patients with stage I NSCLC to identify a subset of patients at high risk for disease recurrence and subsequent mortality. METHODS. Between 1989 and 2003, 19,702 incident cases of stage I NSCLC in the CCR were identified and subgrouped into stage IA and IB disease. Patient demographic factors, tumor characteristics, and treatment delivered were examined. Kaplan‐Meier survival curves were calculated to estimate survival rates. Cox proportional‐hazards ratios were used to identify independent prognostic factors for survival. RESULTS. Advanced age at diagnosis, male sex, low socioeconomic status (SES), nonsurgical treatment, and poor histologic grade (stage IA NSCLC: hazards ratio [HR], 1.13; 95% confidence interval [95% CI], 1.08–1.19; stage IB NSCLC: HR, 1.11; 95% CI, 1.07–1.16) were associated with increased mortality risk on multivariate analysis. Nonupper lobe tumor location (right middle lobe, right and left lower lobes) and tumor size ≥4 cm (vs <4 cm: HR, 1.23; 95% CI, 1.15–1.30) were additional factors that increased the risk of mortality among patients with stage IB disease. Bronchioloalveolar carcinoma and Asian ethnicity were associated with decreased mortality risk in stage I NSCLC. CONCLUSIONS. Stage I NSCLC with poorly differentiated histology and stage IB NSCLC with nonupper lobar tumor location or tumor size ≥4 cm carried an increased mortality risk. Cancer 2007. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival of stage I nonsmall cell lung cancer patients

Zell

Ziogas

et al. 2007

Cancer

190

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“…Hsu et al 78) reported that median survival was the same for never-smoking women and never-smoking men with adenocarcinoma, suggesting that both smoking status and histologic type rather than gender decided survival. In several studies, 34,40,70) a significant survival advantage for women disappeared after statistically adjusting for smoking status, although in other studies 28,41,49,51,53,57,58,76,77) survival advantages for women persisted after adjustment for smoking. In our meta-analysis, which combined these conflicting studies, female gender still persisted as a favorable prognostic factor, independent of smoking status.…”

Section: Figmentioning

confidence: 94%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

ATCS

114

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Purpose: It is not clear whether women with non-small-cell lung cancer (NSCLC) live significantly longer than men. Thus, we conducted a meta-analysis of published studies to quantitatively compare NSCLC survival data between genders. Materials and Methods: A MEDLINE Web search for computer-archived bibliographic data regarding overall survival differences between genders was performed. DerSimonian-Laird random effects analysis was used to estimate the pooled hazard ratio (HR). Results: We selected 39 articles as appropriate data sources, involving 86 800 patients including 32 701 women and 54 099 men. Combined HRs for women vs. men in studies using univariate and multivariate analyses respectively were 0.79 (p <0.0001) and 0.78 (p <0.0001). Pooled HRs for 3 study subgroups having (1) fewer than 30% stage I cases, (2) fewer than 50% adenocarcinoma cases, and (3) statistical adjustment for smoking status all indicated the survival advantage of women. Conclusion: This meta-analysis of published data concerning NSCLC patients indicated significantly better survival for women.

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“…Other poor prognostic factors in early stage disease are age, male gender and non-squamous histology (Ioannidis et al, 2011). Grade, lymphovascular invasion (LVI), visceral pleural invasion have been reported as important for poor prognosis in retrospective analysis (Sun et al, 2006;Ioannidis et al, 2011). These parameters have been used for decision in adjuvant chemotherapy in early stage NSCLC (Ioannidis et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors for Lymph Node Negative Stage I and IIA Non-small Cell Lung Cancer: Multicenter Experiences

Ustaalioğlu

Ünal²,

Turan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Histologic grade is an independent prognostic factor for survival in non–small cell lung cancer: An analysis of 5018 hospital- and 712 population-based cases

Abstract: Histologic grade has significant prognostic value for survival of patients with non-small cell lung cancer. Histologic grade may provide useful information in defining the aggressiveness of tumors and should be considered as an independent factor affecting survival beyond TNM staging.

Cited by 130 publications

References 22 publications

Prognostic factors for survival of stage I nonsmall cell lung cancer patients

Prognostic factors for survival of stage I nonsmall cell lung cancer patients

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Prognostic Factors for Lymph Node Negative Stage I and IIA Non-small Cell Lung Cancer: Multicenter Experiences

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