Prognostic Factors for Lymph Node Negative Stage I and IIA Non-small Cell Lung Cancer: Multicenter Experiences

Ustaalioğlu, Bala Basak Oven; Ünal, Olçun Ümit; Turan, Nedim; Bılıcı, Ahmet; Kaya, Serap; Eren, Tulay; Ulaş, Arife; İnal, Ali; Berk, Velı; Demırcı, Umut; Alıcı, Süleyman; Bal, Öznur; Benekli, Mustafa; Gümüş, Mahmut

doi:10.7314/apjcp.2013.14.11.6287

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…At last but not least, the multivariate analysis showed also a significant (p=0.045) prognostic value of P serum levels. The stage and PS also had a significant impact, which is in accordance with several publications (Babacan et al, 2014;Inal et al, 2013;Oven Ustaalioglu et al, 2013). Arslan et al (2014) among 122 non-small lung cancer patients with advanced stage showed that age, PS and stage were independent prognostic factors for survival.…”

Section: Discussionsupporting

confidence: 89%

Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study

Kouloulias¹,

Tolia²,

Tsoukalas³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aim of the study was to determine whether the expression of baseline phosphorus (P) and magnesium (Mg) levels were prognostic in terms of stage and overall survival (OS) in newly diagnosed non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients. Materials and Methods: Retrospectively, 130 patients were selected at the time of diagnosis oflung cancer (100 with NSCLC and 30 with SCLC), before the initialization of any chemo-radiotherapy. The median age was 67 (range 29-92). IA, IB, IIA, IIB, IIIA, IIIB and IV stages were present in 3, 4, 19, 6, 25, 8, and 65 patients, respectively. After centrifugation, the levels of serum P and Mg were measured using the nephelometric method/ photometry and evaluated before any type of treatment. Results: Higher than normal levels of P were found in 127/130 patients, while only four patients had elevated Mg serum values. In terms of Spearman test, higher P serum values correlated with either stage (rho=-0.334, p<0.001) or OS (rho=-0.212, p=0.016). Additionally, a significant negative correlation of Mg serum levels was found with stage of disease (rho=-0.135, P=0.042). On multivariate cox-regression survival analysis, only stage (p<0.01), performance status (p<0.01) and P serum (p=0.045) showed a significant prognostic value. Conclusions: Our study indicated that pre-treatment P serum levels in lung cancer patients are higher than the normal range. Moreover, P and Mg serum levels are predictive of stage of disease. Along with stage and performance status, the P serum levels had also a significant impact on survival. This information may be important for stratifying patients to specific treatment protocols or intensifying their therapies. However, larger series are now needed to confirm our results.

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Section: Discussionsupporting

confidence: 89%

Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study

Kouloulias¹,

Tolia²,

Tsoukalas³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Among the 95 patients, there was no significant difference in DFS and OS between patients who received adjuvant chemotherapy and those who did not. Taken together with previous studies, 19 , 20 VPI might not be a useful factor to determine whether patients with stage Ib disease should receive adjuvant chemotherapy. We also noticed that stage Ib patients with solid predominant growth pattern and who received adjuvant chemotherapy had longer DFS and OS than those who did not, but without statistical significance.…”

Section: Discussionmentioning

confidence: 60%

The predictive and prognostic values of factors associated with visceral pleural involvement in resected lung adenocarcinomas

Zhang¹,

Chen

Lu³

et al. 2016

OTT

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BackgroundThe predictive and prognostic impact of factors associated with visceral pleural invasion (VPI) on survival and recurrence in patients with resected lung adenocarcinomas is not clearly defined.Patients and methodsA total of 505 consecutive patients with stage Ia–IIIa lung adenocarcinomas treated with radical resection were included. The predominant growth pattern was classified according to the new classification system for lung adenocarcinoma proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society. The correlations of VPI with clinical and pathologic parameters were analyzed.ResultsThe incidence of VPI was significantly lower in lepidic predominant group (15.5% vs 4.5%, P<0.001) and higher in solid and micropapillary predominant group (28.6% vs 17.6%, P=0.004 and 14.7% vs 4.2%, P<0.001, respectively). VPI correlated with higher risk in regional postoperative recurrence (hazard ratio, 2.341; 95% confidence interval, 1.564–3.504) and distant recurrence (hazard ratio, 2.193; 95% confidence interval, 1.665–2.89) in surgically resected lung adenocarcinomas. However, when growth patterns of adenocarcinoma were lumped into multivariate analysis, VPI was not a significant independent predictive factor for survival (P=0.854 for overall survival [OS] and P=0.575 for disease-free survival [DFS]) and recurrence (P=0.38 for regional recurrence and P=0.089 for distant recurrence). Of the 95 patients with stage Ib, those who received adjuvant chemotherapy had longer DFS and OS than the patients who received no chemotherapy after surgery. However, these differences in DFS and OS did not reach statistical significance (P=0.063 for DFS, P=0.85 for OS).ConclusionVPI was associated with solid and micropapillary histology. In addition, stage Ib patients with solid histologic subtype tumor showed longer DFS and OS, highlighting a potential benefit in this subgroup of patients and necessitating the need for larger clinical trials.

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“…Lung cancers rank the top of cancer-related death with increasing morbidity around the world (Aydiner et al, 2013;Cai et al, 2013;Kaya et al, 2013;Mutlu et al, 2013;Natukula et al, 2013;Oven et al, 2013;Unal et al, 2013;Wang et al, 2013). At present, the chemotherapeutic protocols for NSCLC mainly apply platinums as basic drugs combining with the third generation chemotherapeutic drugs such as paclitaxel, gemcitabine and vinorelbine, etc..…”

Section: Discussionmentioning

confidence: 99%

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

Qiu¹,

Zhao²

2014

Asian Pacific Journal of Cancer Prevention

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Prognostic Factors for Lymph Node Negative Stage I and IIA Non-small Cell Lung Cancer: Multicenter Experiences

Cited by 10 publications

References 22 publications

Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study

Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study

The predictive and prognostic values of factors associated with visceral pleural involvement in resected lung adenocarcinomas

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

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