Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates

Peckham, Steven J.; Sloan, Brett; Elston, Dirk M.

doi:10.1016/j.jaad.2011.02.017

Cited by 52 publications

(58 citation statements)

References 15 publications

(21 reference statements)

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“…Peckham et al . [48] detected the presence of eosinophils in fibrous tracts and in peribulbar infiltrates in 44% of examined AA biopsies and concluded that eosinophilic infiltration in fibrous tracts and near hair bulbs is a helpful diagnostic feature of AA, especially when biopsy specimens lack the peribulbar lymphocytic infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Total serum immunoglobulin E in patients with alopecia areata

Bakry

Shazly

Basha

et al. 2014

Indian Dermatol Online J

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Context:Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The pathogenesis of the disease is unknown. Previous evidence suggested the involvement of Th2 cytokines in disease pathogenesis.Aim:To determine serum level of total IgE, this is mainly influenced by Th2 cytokines, in Egyptian patients with AA.Materials and Methods:Fifty subjects with AA (28 males and 22 females) were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital from February 2012 to December 2012. Subjects with other conditions that might elevate serum IgE were excluded from the study. Fifty age- and sex-matched healthy subjects were selected as a control group. Venous blood samples were taken from cases and controls for measurement of total serum IgE by enzyme-linked immunosorbent assay. Skin biopsy was taken from every case from an active area of hair loss.Results:Total serum IgE was elevated in 27 (54%) cases. Its values among patients ranged from 13.5 IU/ml to 780 IU/ml. There was a statistically significant difference between cases and controls with regard to mean value of serum IgE (P < 0.05). Mean value of IgE did not vary significantly with disease severity, patients’ age, patients’ gender, disease duration, site of lesions, and positive family history of AA. No correlation was found between serum IgE levels and histopathological changes detected in examined cases.Conclusions:Total serum IgE is elevated in AA. This elevation is not related to age, gender, disease duration, disease severity, site of affection or family history of AA.

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Section: Discussionmentioning

confidence: 99%

Total serum immunoglobulin E in patients with alopecia areata

Bakry

Shazly

Basha

et al. 2014

Indian Dermatol Online J

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“…Eosinophil infiltration into the skin lesions at any stage is a useful diagnostic feature of AA (7,8). However, it is not known whether basophils infiltrate into AA skin lesions.…”

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confidence: 99%

No Basophil Infiltration in Alopecia Areata Irrespective of the Intensity of Eosinophil Infiltration

Ono¹,

Otsuka²,

Kabashima³

2013

Acta Derm Venerol

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“…This finding was not observed in other studies by Chaitra et al [19] and Singh et al [14]. Presence of lymphocytes in fibrous stelae has also been suggested as an indicator of AA, reported in 41-94% of cases [12,14,17]. Miteva et al [12] in their study on 46 cases of alopecia incognita found dilated follicular openings in 91% of cases which corresponded to the presence of yellow dots on dermoscopy.…”

mentioning

confidence: 74%

“…Pigment casts are frequently seen in AA. Peckham et al [17] noticed melanin in fibrous stelae in 84% of AA cases and considered it to be an important clue to diagnose this condition. Similarly in an Indian study, Singh et al [14] found melanin in vascular stelae in 83% of AA cases on horizontal sections and 80% of biopsies on vertical sections.…”

Section: Discussionmentioning

confidence: 99%

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Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata

et al. 2018

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Background: Androgenetic alopecia (AGA) and alopecia areata (AA) are common causes of alopecia which can sometimes be difficult to differentiate clinically. Horizontal sections of scalp biopsies are used to study non-cicatricial alopecias due to the ability to perform both quantitative and morphometric analysis of hair follicles on them. Methods: It was a prospective, cross-sectional study conducted to assess the utility of horizontal sections to differentiate between the alopecias. Fifty-two cases were included: 20 cases of male AGA, 11 of female AGA and 21 cases of AA. After clinical examination and dermoscopy, a skin biopsy was taken and subjected to transverse sectioning. Histopathological assessment was done by two dermatopathologists blinded to clinical details. Results: Among the quantitative parameters, terminal:vellus hair ratio (3.08 in AGA and 1.83 in AA, p = 0.0091) and anagen:non-anagen hair ratio (9.25 in AGA and 3.56 in AA, p = 0.0021) were significantly lower in AA. In qualitative parameters, peribulbar inflammation was seen in 63% of AA cases (p = 0.0001). Pigment casts were seen in twice the number of AA (57%) than AGA (26%) cases. Broad avascular stelae and focal trichomalacia were seen in 9.5% of AA cases. Conclusion: Besides peribulbar inflammation, we found a lower anagen:non-anagen hair ratio and presence of pigment casts in transverse sections of scalp biopsies favouring AA over AGA.

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Histologic features of alopecia areata other than peribulbar lymphocytic infiltrates

Cited by 52 publications

References 15 publications

Total serum immunoglobulin E in patients with alopecia areata

Total serum immunoglobulin E in patients with alopecia areata

No Basophil Infiltration in Alopecia Areata Irrespective of the Intensity of Eosinophil Infiltration

Utility of Horizontal Sections of Scalp Biopsies in Differentiating between Androgenetic Alopecia and Alopecia Areata

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