Histologic Examination of the Bone Marrow

Mark, TM; Levin, Adam S.

doi:10.1097/00007611-198112000-00008

Cited by 5 publications

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“…Investigators working primarily with adult non-Hodgkin's lymphoma patients generally consider bone marrow biopsy to be essential in the evaluation of bone marrow disease [1][2][3][4][5]131. The published literature on adults concerns mostly older patients in the range of 50-60 years of age.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow involvement in young patients with non‐Hodgkin's lymphoma: The importance of multiple bone marrow samples for accurate staging

Haddy

Parker

Magrath

1989

Med. Pediatr. Oncol.

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Of 95 young patients with non‐Hodgkin's lymphoma treated at the National Cancer Institute on Pediatric Branch Protocol 7704, 18 (18.9%) had bone marrow involvement prior to treatment. Their mean age was 20.5 years. Twelve patients had small, noncleaved lymphoma (ten Burkitt's and two undifferentiated, unspecified), five had lymphoblastic lymphoma, and one had a diffuse large cell lymphoma. All had extensive disease. We obtained bilateral bone marrow biopsy specimens, touch preparations, clot sections, and aspirate smears from 13 of the 18 patients. When paired contralateral samples were reviewed, in as many as six out of ten of the pairs only one side was positive for tumor. When paired ipsilateral samples were similarly reviewed, in as many as seven out of 21 of the pairs only one specimen was positive for tumor. The biopsy specimen was the most useful of the four types of study performed, yielding positive results in 87% of the preparations. Thus, in a high percentage of patients, multiple marrow sampling revealed disease that might have been missed if fewer specimens had been obtained. Only four of our 18 patients (22.2%) had long‐term remissions. Because young patients with marrow disease are at high risk and may be eligible for more intensive treatment protocols, we recommend that staging should include bilateral bone marrow biopsies and bilateral aspirates.

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Section: Discussionmentioning

confidence: 99%

Bone marrow involvement in young patients with non‐Hodgkin's lymphoma: The importance of multiple bone marrow samples for accurate staging

Haddy

Parker

Magrath

1989

Med. Pediatr. Oncol.

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“…The traditional donor site for a sufficient amount of bone marrow for diagnostic and therapeutic purposes is the hip region. The classic puncture is performed with a percutaneous needle biopsy at the posterior superior iliac crest (Jamshidi puncture) entailing an additional extraoral and painful intervention for the patient (Mark & Levin ). Little information is available about the efficacy of less invasive alternative bone marrow (BM) donor sites than the hip region with regard to the amount of harvested bone marrow and type as well as number of expandable cells.…”

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confidence: 99%

Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants

Payer

Lohberger

Strunk

et al. 2013

Clinical Oral Implants Res

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“…The aspirate particles are fixed by using acetic acid-zinc-formalin (AZF) - a fixative agent followed by sectioning, and staining. One of the studies used in this procedure and showed that preparation of the histologic sections by this method is superior in contrast to the BMB for the investigation of lipid granuloma, nodular lymphoid hyperplasia, and lymphoid nodules [ 25 ]. The filtered blood is then centrifuged at a particular speed (rpm or g) remaining leads to the formation of four layers: fat layer and layer of peri-vascular cells, plasma layer, a layer of myeloid-erythroid cells (buffy coat), and red blood corpuscles (RBC) layer [ 26 ].…”

Section: Reviewmentioning

confidence: 99%

Bone Marrow Aspiration and Biopsy in Critical Pediatric Patients: A Pathologist’s Perspective

Bhaskar¹

2021

Cureus

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Bone marrow aspiration (BMA) and bone marrow biopsy (BMB), are medical modalities for the detection of non-malignant diseases as well as hematological malignancies in children. BMA attained momentum in the past few years owing to the possibility of achieving hematopoietic stem cells. Liquid bone marrow is aspirated through posterior/anterior iliac crest, tibia, and vertebral spinous process during BMA procedure in children for assessment of morphology at the microscopic level while BMB allows for cytological evaluation of marrow. It is also used for molecular genetics, immune-phenotypic, cytogenetics, and other specialized examinations. Additionally, BMA is also helpful in the reconstruction of tissue. These procedures should be performed by a specialist who has knowledge about the indication, contradictions, and hazards of these procedures due to their invasive nature. Still, there are no transparent guidelines available especially in the case of BMA for children. The purpose of this overview article is to focus on the specific guidelines to carry out the BMA and BMB in children and the techniques as well as complications associated with the BMA and BMB.

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Histologic Examination of the Bone Marrow

Cited by 5 publications

References 0 publications

Bone marrow involvement in young patients with non‐Hodgkin's lymphoma: The importance of multiple bone marrow samples for accurate staging

Bone marrow involvement in young patients with non‐Hodgkin's lymphoma: The importance of multiple bone marrow samples for accurate staging

Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants

Bone Marrow Aspiration and Biopsy in Critical Pediatric Patients: A Pathologist’s Perspective

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