Histologic Evolution of Basal Cell Carcinoma Recurrence

Basal Cell Carcinoma with Mixed Histology: A Possible Pathogenesis for Recurrent Skin Cancer

“…The histologic subtype of basal cell carcinoma influences the biologic behavior of the tumor. Recurrent basal cell carcinomas are commonly associated with a primary cancer that has an aggressive histologic subtype 3,53–57 . Also, basal cell carcinomas with aggressive histologic patterns require more aggressive treatment; in addition, when the Mohs micrographic surgical technique is used, a greater number of stages are required to achieve tumor free margins as compared with basal cell carcinomas without aggressive tumor growth patterns 3–5,58 …”

Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas

“…4,13 BSCC -Dermal infiltration of nests of basaloid cells, with peripheral palisading demonstrating foci of squamous cells with intercellular bridges and epithelial pearls. Both pseudoepithelial hyperplasia associated with BCC and the keratinizing form of BCC were excluded.…”

An Overview on Basal Cell Carcinoma

“…The histologic subtype of BCC influences the biologic behavior of the tumor. Recurrent BCCs are commonly associated with a primary cancer that has an aggressive histologic subtype (95)(96)(97)(98).…”